Ketoconazole beyond antifungal activity: Bioinformatics‐based hypothesis on lipid metabolism in dandruff and seborrheic dermatitis

The role of Malassezia yeasts in dandruff and seborrheic dermatitis is unclear; however, antifungal therapy with ketoconazole is commonly used. We propose that ketoconazole shifts skin lipid profile, affects Malassezia lipid metabolism and favours biotin‐producing bacteria. Biotin regulates inflamma...

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Bibliographic Details
Published in:Experimental dermatology 2022-05, Vol.31 (5), p.821-822
Main Authors: Goularte‐Silva, Vinicius, Paulino, Luciana Campos
Format: Article
Language:English
Subjects:
Antifungal activity
Antifungal Agents - pharmacology
Bioinformatics
Biotin
Cell proliferation
Computational Biology
Dandruff - drug therapy
Dandruff - microbiology
Dermatitis
Dermatitis, Seborrheic - drug therapy
Dermatitis, Seborrheic - microbiology
Humans
Inflammation
Ketoconazole
Ketoconazole - pharmacology
Lipid Metabolism
Lipids
Malassezia
Metabolism
microbiota
Seborrheic dermatitis
skin
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Summary:The role of Malassezia yeasts in dandruff and seborrheic dermatitis is unclear; however, antifungal therapy with ketoconazole is commonly used. We propose that ketoconazole shifts skin lipid profile, affects Malassezia lipid metabolism and favours biotin‐producing bacteria. Biotin regulates inflammatory response and cell proliferation, contributing to symptom improvement.
ISSN:0906-6705
1600-0625
DOI:10.1111/exd.14505