Metal‐Based Aggregation‐Induced Emission Theranostic Systems

Efficient theranostic systems can realize better outcomes in disease treatment because of precise diagnosis and the concomitant effective therapy. Aggregation‐induced emission luminogens (AIEgens) are a unique type of organic emitters with intriguing photophysical properties in the aggregate state....

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Bibliographic Details
Published in:ChemMedChem 2022-02, Vol.17 (3), p.e202100578-n/a
Main Authors: Shen, Hanchen, Xu, Changhuo, Sun, Feiyi, Zhao, Mengying, Wu, Qian, Zhang, Jianyu, Li, Sijie, Zhang, Jing, Lam, Jacky W. Y., Tang, Ben Zhong
Format: Article
Language:English
Subjects:
Agglomeration
Aggregation-induced emission
Biomedical materials
Cell Line
Coordination Complexes - chemistry
Emission
Emissions
Emitters
Fluorescent Dyes - chemistry
Humans
Medical imaging
Medical treatment
Metal-based system
Metals, Heavy - chemistry
Molecular Structure
Nanotechnology
Optical Imaging
Photochemistry
Precision Medicine
Theranostic Nanomedicine
Theranostics
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Summary:Efficient theranostic systems can realize better outcomes in disease treatment because of precise diagnosis and the concomitant effective therapy. Aggregation‐induced emission luminogens (AIEgens) are a unique type of organic emitters with intriguing photophysical properties in the aggregate state. Among the AIEgens studied for biomedical applications, so far, metal‐based AIE systems have shown great potential in theranostics due to the enhanced multimodal bioimaging ability and therapeutic effect. This research field has been growing rapidly, and many rationally designed systems with promising activities to cancer and other diseases have been reported recently. In this review, we summarized the recent progress of metal‐based AIE materials in bioimaging and biological theranostics, and deciphered the pertinent design strategies. We hope that this review can offer new insights into the development of this growing field. Coming together: Theranostic systems combine precise diagnosis and effective therapy and thus are vital in modern medicine. The integration of aggregation‐induced emission luminogens (AIEgens) with metal elements can provide multifunctional theranostic systems. Recent advances in metal‐based AIE theranostic systems are discussed in this minireview.
ISSN:1860-7179
1860-7187
DOI:10.1002/cmdc.202100578