Evaluation of Hepatoprotective effects of different doses of Lyophilized Beetroot powder in albino rabbits

Beta vulgaris L. is a vegetable most commonly consumed in salads and has been shown to possess multiple benefits. This research was carried out to observe the effects of Beta vulgaris powder at different doses orally in albino rabbits on liver biochemical parameters and coagulation. The study was ca...

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Bibliographic Details
Published in:Pakistan journal of pharmaceutical sciences 2021-09, Vol.34 (5(Supplementary)), p.1917-1922
Main Authors: Sarfaraz, Sana, Ikram, Rahela, Munawwar, Rabia, Fatima, Sakina, Anser, Humera, Fatima, Mahwish
Format: Article
Language:English
Subjects:
Alanine Transaminase - analysis
Animals
Aspartate Aminotransferases - analysis
Beta vulgaris - chemistry
Blood Coagulation
Dietary Supplements
Dose-Response Relationship, Drug
Fibrinogen - analysis
Fibrinogen - metabolism
Freeze Drying
Liver - drug effects
Liver Diseases - prevention & control
Liver Function Tests
Plant Roots
Powders
Protective Agents - pharmacology
Prothrombin Time
Rabbits
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Summary:Beta vulgaris L. is a vegetable most commonly consumed in salads and has been shown to possess multiple benefits. This research was carried out to observe the effects of Beta vulgaris powder at different doses orally in albino rabbits on liver biochemical parameters and coagulation. The study was carried out on albino rabbits which were divided into three groups designated as Group I (administered distilled water) Group II and III (administered beetroot powder at 500mg/kg and 1000mg/kg dose respectively) orally for 2 month duration. The sample was withdrawn at day 0, 30th and 60th day through cardiac puncture. The results showed that both doses of Beta vulgaris were considered safe for use as all the liver parameters were significantly decreased compared to control. Among both doses 500mg/kg dose was considered safer as it reduced the parameters significantly compared to 1000mg/kg dose. Blood coagulation factors at both the doses showed significant increase which was in reference range. Beta vulgaris is a highly beneficial dietary product with ample amount of flavonoids and anti-oxidant agents which might help in improving the liver function and also play a role in coagulation by increasing both fibrinogen levels and prothrombin time.
ISSN:1011-601X
DOI:10.36721/PJPS.2021.34.5.SUP.1917-1922.1