MEOX1 suppresses the progression of lung cancer cells by inhibiting the cell‐cycle checkpoint gene CCNB1

The previous study has shown that transcriptional factor MEOX1 could promote proliferation and sphere formation ability of non‐small cell lung cancer (NSCLC) cells, however, we found that MEOX1 mRNA was lowly expressed in lung cancer tissues compared to that in normal adjacent tissues, and MEOX1 mRN...

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Bibliographic Details
Published in:Environmental toxicology 2022-03, Vol.37 (3), p.504-513
Main Authors: Xiao, Xie, Rui, Bi, Rui, Hu, Ju, Mei, Hongtao, Liu
Format: Article
Language:English
Subjects:
Adenocarcinoma
Apoptosis
Cancer
Carcinoma, Non-Small-Cell Lung - genetics
CCNB1
Cell cycle
Cell Line, Tumor
Cell Proliferation
Cells
Cyclin B1
G2 phase
Gene expression
Gene Expression Regulation, Neoplastic
Genes, cdc
Homeodomain Proteins - genetics
Humans
Lung cancer
Lung Neoplasms - genetics
Lungs
MEOX1
Non-small cell lung carcinoma
non‐small cell lung cancer
Proliferation
Small cell lung carcinoma
Survival
Tissue
Transcription Factors
transcriptional initiation
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Summary:The previous study has shown that transcriptional factor MEOX1 could promote proliferation and sphere formation ability of non‐small cell lung cancer (NSCLC) cells, however, we found that MEOX1 mRNA was lowly expressed in lung cancer tissues compared to that in normal adjacent tissues, and MEOX1 mRNA expression was positively correlated with the survival of lung cancer patients, especially in lung adenocarcinoma patients. Functional experiments using in vitro and in vivo experiments revealed that stable overexpression of MEOX1 significantly suppressed the proliferation ability, promoted cell cycle arrest in G2 phase, and apoptotic ability of NSCLC cells. Additionally, it was identified that MEOX1 and CCNB1 mRNA expression exhibited a negative correlation in different lung cancer tissues. Mechanistically, we indicated that MEOX1 bound to the transcriptional initiation site of CCNB1 and thus suppressed CCNB1 expression. Notably, CCNB1 overexpression rescued the inhibition of MEOX1 overexpression on NSCLC progression. This study deciphers a novel MEOX1/CCNB1 axis suppressing NSCLC progression.
ISSN:1520-4081
1522-7278
DOI:10.1002/tox.23416