Abundance of estrogen receptors involved in non-canonical signaling in the dog testis

With estrogen regulation of the reproductive system, G-protein-coupled membrane estrogen receptor (GPER) and estrogen-related receptors (ERRs) are implicated. Non-canonical receptors can bind estrogens such as environmental and pharmacological chemicals. These compounds induce rapid non-genomic path...

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Bibliographic Details
Published in:Animal reproduction science 2021-12, Vol.235, p.106888-106888, Article 106888
Main Authors: Galuszka, Anna, Pawlicki, Piotr, Pardyak, Laura, Chmurska-Gąsowska, Maria, Pietsch-Fulbiszewska, Agnieszka, Duliban, Michal, Turek, Wiktor, Dubniewicz, Klaudia, Ramisz, Grzegorz, Kotula-Balak, Malgorzata
Format: Article
Language:English
Subjects:
Animals
Dog
Dogs - physiology
Estrogen-related receptor
G-protein-coupled estrogen receptor
Male
Receptors, Estrogen - genetics
Signal Transduction
Testis
Testis - metabolism
Tumor
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Summary:With estrogen regulation of the reproductive system, G-protein-coupled membrane estrogen receptor (GPER) and estrogen-related receptors (ERRs) are implicated. Non-canonical receptors can bind estrogens such as environmental and pharmacological chemicals. These compounds induce rapid non-genomic pathways or receptor interaction including autoactivation. Testicular tumors occur in dogs more frequently than in other domestic animals. Also, in recent decades there were increased occurrences of various tumor types in dogs. Using qRT-PCR, Western blot and immunohistochemistry procedures in the present study, there was determination of abundance pattern of GPER, ERRα, β and γ in dog tests when there were intratubular germ cell tumors. There was quantitation of estradiol, cyclic GMP and calcium ions (Ca2+). There were changes (P 
ISSN:0378-4320
1873-2232
DOI:10.1016/j.anireprosci.2021.106888