Biofilms in tuberculosis: What have we learnt in the past decade and what is still unexplored?

Elucidating how Mycobacterium tuberculosis produces biofilms, and its impact for tuberculosis (TB) pathogenesis is gaining momentum. Here, we discuss recent findings reported over the last decade, which help us gain insights into the association between biofilm formation and TB pathogenesis. A new a...

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Bibliographic Details
Published in:Tuberculosis (Edinburgh, Scotland) Scotland), 2022-01, Vol.132, p.102153-102153, Article 102153
Main Authors: Bacon, Joanna, Waddell, Simon J., Flores-Valdez, Mario Alberto
Format: Article
Language:English
Subjects:
Antitubercular Agents - pharmacology
Biofilms
Biofilms - drug effects
Biofilms - growth & development
Extracellular communities
Humans
Mycobacterium
Mycobacterium tuberculosis - genetics
Pathogenesis
Phenotypes
Pulmonary pathogenesis
Tuberculosis
Tuberculosis - metabolism
Tuberculosis - microbiology
Vaccines
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Summary:Elucidating how Mycobacterium tuberculosis produces biofilms, and its impact for tuberculosis (TB) pathogenesis is gaining momentum. Here, we discuss recent findings reported over the last decade, which help us gain insights into the association between biofilm formation and TB pathogenesis. A new appreciation of extracellular TB phenotypes found in lung lesions will drive drug and vaccine discovery forward to new possibilities.
ISSN:1472-9792
1873-281X
DOI:10.1016/j.tube.2021.102153