Differences in recipient ability of uropathogenic Escherichia coli strains in relation with their pathogenic potential

Conjugation is recognized as a mechanism driving dissemination of antibacterial resistances and virulence factors among bacteria. In the presented work conjugative transfer frequency into clinical uropathogenic Escherichia coli strains (UPEC) isolated from patients with symptomatic urinary tract inf...

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Published in:Infection, genetics and evolution genetics and evolution, 2022-01, Vol.97, p.105160-105160, Article 105160
Main Authors: Kuznetsova, Marina V., Maslennikova, Irina L., Pospelova, Julia S., Žgur Bertok, Darja, Starčič Erjavec, Marjanca
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Antibiotic resistance
Bacterial conjugation
Bacteriocin insensitivities
Biofilm
Biofilms - drug effects
Drug Resistance, Bacterial - genetics
Escherichia coli Infections - microbiology
Plankton - drug effects
Urinary Tract Infections - microbiology
Uropathogenic Escherichia coli - drug effects
Uropathogenic Escherichia coli - pathogenicity
Uropathogenic Escherichia coli strains
Virulence Factors - genetics
Virulence-associated genes
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Summary:Conjugation is recognized as a mechanism driving dissemination of antibacterial resistances and virulence factors among bacteria. In the presented work conjugative transfer frequency into clinical uropathogenic Escherichia coli strains (UPEC) isolated from patients with symptomatic urinary tract infections was investigated. From 93 obtained UPEC strains only 29 were suitable for conjugation experiments with the plasmid pOX38, a well-known F-plasmid derivative. The study was focused on comparison of conjugation frequencies in plankton and biofilm, including comparison of conjugation frequencies in high and low biofilm biomass with their virulence potential. It was shown that the conjugation frequency depended on the biofilm biomass and was significantly higher in thin (OD580 
ISSN:1567-1348
1567-7257
DOI:10.1016/j.meegid.2021.105160