Effects of mechanical properties of gelatin methacryloyl hydrogels on encapsulated stem cell spheroids for 3D tissue engineering

Cell spheroids are three-dimensional cell aggregates that have been widely employed in tissue engineering. Spheroid encapsulation has been explored as a method to enhance cell-cell interactions. However, the effect of hydrogel mechanical properties on spheroids, specifically soft hydrogels (

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Bibliographic Details
Published in:International journal of biological macromolecules 2022-01, Vol.194, p.903-913
Main Authors: Kim, Eun Mi, Lee, Gyeong Min, Lee, Sangmin, Kim, Se-jeong, Lee, Dongtak, Yoon, Dae Sung, Joo, Jinmyoung, Kong, Hyunjoon, Park, Hee Ho, Shin, Heungsoo
Format: Article
Language:English
Subjects:
Apoptosis
Cell Culture Techniques
Cell Proliferation
Cell Survival
Chemical Phenomena
Encapsulation
Gelatin - chemistry
Gelatin methacryloyl
Humans
Hydrogels - chemistry
Mechanical Phenomena
Methacrylates - chemistry
Spheroid-laden hydrogel
Spheroids, Cellular
Stem cell spheroid
Stem Cells - cytology
Temperature
Tissue Engineering - methods
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Description
Summary:Cell spheroids are three-dimensional cell aggregates that have been widely employed in tissue engineering. Spheroid encapsulation has been explored as a method to enhance cell-cell interactions. However, the effect of hydrogel mechanical properties on spheroids, specifically soft hydrogels (
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2021.11.145