Helicobacter pylori infection and the progression of atherosclerosis: A systematic review and meta‑analysis

Objective In recent years, many studies have tried to prove whether Helicobacter pylori (H. pylori) can promote the progression of atherosclerosis (AS), but the reported results are conflicting. Carotid intima‐media thickness (CIMT), flow‐mediated dilation (FMD), or pulse wave velocity (PWV) are the...

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Published in:Helicobacter (Cambridge, Mass.) Mass.), 2022-02, Vol.27 (1), p.e12865-n/a
Main Authors: Shi, Hongshuo, Li, Yinghao, Dong, Chengda, Si, Guomin, Xu, Yunsheng, Peng, Min, Li, Yujie
Format: Article
Language:English
Subjects:
Arteriosclerosis
Atherosclerosis
Cardiovascular disease
Cardiovascular diseases
Carotid Intima-Media Thickness
Clinical trials
Cross-Sectional Studies
Health risks
Helicobacter Infections
Helicobacter pylori
Helicobacter pylori infection
Humans
Indicators
Infections
Meta-analysis
Middle Aged
Older people
Pulse Wave Analysis
Risk analysis
Risk Factors
Subgroups
Wave velocity
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Summary:Objective In recent years, many studies have tried to prove whether Helicobacter pylori (H. pylori) can promote the progression of atherosclerosis (AS), but the reported results are conflicting. Carotid intima‐media thickness (CIMT), flow‐mediated dilation (FMD), or pulse wave velocity (PWV) are the most commonly used indicators to evaluate the progress of AS. So, we collected and evaluated these three indicators to provide evidence‐based medicine for the clinic. Materials and methods We included and evaluated studies on H. pylori infection and CIMT, FMD, or PWV from PubMed, Cochrane trials, and Embase databases before September 1, 2021, and language restrictions: English. Research types include cross‐sectional studies, cohort studies, and case‐control studies. The MINORS scale was used to evaluate the quality of these studies. For all studies, we choose a random‐effects model and calculate the weighted mean difference (WMD) for analysis, and all our analyses use STATA software. Results Meta‐analysis shows that H. pylori infection can significantly increase CIMT (WMD = 0.059, 95% CI: 0.039, 0.079, p 
ISSN:1083-4389
1523-5378
DOI:10.1111/hel.12865