The Functions of Long Non-Coding RNA (lncRNA) H19 in the Heart

Cardiovascular diseases (CVDs) are major causes of morbidity and mortality worldwide. Great effort has been put into exploring early diagnostic biomarkers and innovative therapeutic strategies for preventing CVD progression over the last two decades. Long non-coding RNAs (lncRNAs) have been identifi...

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Bibliographic Details
Published in:Heart, lung & circulation lung & circulation, 2022-03, Vol.31 (3), p.341-349
Main Authors: Wang, Yao, Sun, Xiaojing, Sun, Xianglan
Format: Article
Language:English
Subjects:
Animals
Cardiomegaly - genetics
Cardiovascular disease
Coronary Artery Disease - genetics
H19 function
Heart
Humans
LncRNA H19
Mice
RNA, Long Noncoding - genetics
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Summary:Cardiovascular diseases (CVDs) are major causes of morbidity and mortality worldwide. Great effort has been put into exploring early diagnostic biomarkers and innovative therapeutic strategies for preventing CVD progression over the last two decades. Long non-coding RNAs (lncRNAs) have been identified as novel regulators in cardiac development and cardiac pathogenesis. For example, lncRNA H19 (H19), also known as a fetal gene abundant in adult heart and skeletal muscles and evolutionarily conserved in humans and mice, has a regulatory role in aortic aneurysm, myocardial hypertrophy, extracellular matrix reconstitution, and coronary artery diseases. Yet, the exact function of H19 in the heart remains unknown. This review summarises the functions of H19 in the heart and discusses the challenges and possible strategies of H19 research for cardiovascular disease.
ISSN:1443-9506
1444-2892
DOI:10.1016/j.hlc.2021.10.022