Sleep-disordered breathing is independently associated with elevated natriuretic peptide levels in patients with cardiovascular diseases

Sleep disorders and sleep duration have attracted considerable attention as potential modifiable risk factors for the development and progression of heart failure (HF). However, whether these sleep behaviors could aggravate the underlying cardiac condition remains ambiguous. We evaluated the associa...

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Bibliographic Details
Published in:Heart and vessels 2022-06, Vol.37 (6), p.994-1002
Main Authors: Sugiura, Kohei, Kohno, Takashi, Kohsaka, Shun, Shiraishi, Yasuyuki, Katsumata, Yoshinori, Hayashida, Kentaro, Yuasa, Shinsuke, Takatsuki, Seiji, Fukuda, Keiichi
Format: Article
Language:English
Subjects:
Biomedical Engineering and Bioengineering
Brain natriuretic peptide
Cardiac Surgery
Cardiology
Cardiovascular diseases
Congestive heart failure
Daytime
Medicine
Medicine & Public Health
Multiple regression analysis
Original Article
Oximetry
Peptides
Respiration
Risk analysis
Risk factors
Sleep
Sleep and wakefulness
Sleep deprivation
Sleep disorders
Sleepiness
Vascular Surgery
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Summary:Sleep disorders and sleep duration have attracted considerable attention as potential modifiable risk factors for the development and progression of heart failure (HF). However, whether these sleep behaviors could aggravate the underlying cardiac condition remains ambiguous. We evaluated the associations between the levels of plasma B-type natriuretic peptide (BNP) and sleep-disordered breathing (SDB), sleep quality and quantity, or daytime sleepiness in cardiovascular diseases (CVD) patients. A total of 1717 consecutive patients with CVD [median age, 66 years (55–74 years); female, 27.5%] were enrolled. SDB was screened by nocturnal pulse oximetry; sleep quality and quantity were determined by Pittsburg Sleep Quality Index, and daytime sleepiness was examined by Epworth Sleepiness Scale. The median plasma BNP level was 54.9 pg/ml (23.5–146.4 pg/ml). Multiple regression analyses showed that the BNP level in the highest quintile (BNP > 181.8 pg/ml) was associated with SDB (severe: OR, 5.88; 95% CI 3.17–10.88; moderate: OR, 3.62; 95% CI 2.17–6.02; mild: OR, 2.22: 95% CI 1.42–3.47). There were no significant associations between other sleep parameters and higher BNP levels. The relationship between SDB and BNP levels was unchanged regardless of the previous history of symptomatic HF. SDB was independently associated with the elevated plasma BNP level in patients with a variety of CVD.
ISSN:0910-8327
1615-2573
DOI:10.1007/s00380-021-01998-6