Application of omics beyond the central dogma in coronary heart disease research: A bibliometric study and literature review

Despite remarkable progress in disease diagnosis and treatment, coronary heart disease (CHD) remains the number one leading cause of death worldwide. Many practical challenges still faced in clinical settings necessitates the pursuit of omics studies to identify alternative/orthogonal biomarkers, as...

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Bibliographic Details
Published in:Computers in biology and medicine 2022-01, Vol.140, p.105069-105069, Article 105069
Main Authors: Lim, Si Ying, Selvaraji, Sharmelee, Lau, Hazel, Li, Sam Fong Yau
Format: Article
Language:English
Subjects:
Bibliometrics
Biomarkers
Cardiovascular disease
Cardiovascular diseases
Citations
Coronary artery disease
Coronary heart disease
Coronary vessels
Coronaviruses
COVID-19
Genomics
Glycomics
Heart attacks
Heart diseases
Keywords
Lipidomics
Literature reviews
Medical research
Metabolomics
Metallomics
Proteomics
Scientometrics
Transcriptomics
Trends
Vein & artery diseases
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Summary:Despite remarkable progress in disease diagnosis and treatment, coronary heart disease (CHD) remains the number one leading cause of death worldwide. Many practical challenges still faced in clinical settings necessitates the pursuit of omics studies to identify alternative/orthogonal biomarkers, as well as to discover novel insights into disease mechanisms. Albeit relatively nascent as compared to the omics frontrunners (genomics, transcriptomics, and proteomics), omics beyond the central dogma (OBCD; e.g., metabolomics, lipidomics, glycomics, and metallomics) have undeniable contributions and prospects in CHD research. In this bibliometric study, we characterised the global trends in publication/citation outputs, collaborations, and research hotspots concerning OBCD-CHD, with a focus on the more prolific fields of metabolomics and lipidomics. As for glycomics and metallomics, there were insufficient publication records on their applications in CHD research for quantitative bibliometrics analysis. Thus, we reviewed their applications in health/disease research in general, discussed and justified their potential in CHD research, and suggested important/promising research avenues. By summarising evidence obtained both quantitatively and qualitatively, this study offers a first and comprehensive picture of OBCD applications in CHD, facilitating the establishment of future research directions. •OBCD-CHD works were analysed quanti-/qualitatively to define research trends.•Bibliometrics analysis of metabolomic/lipidomics works revealed:•High research outputs/impacts on nutrition, shift to multi-omics approaches.•Multidisciplinary collaborations and computational advancements are vital.•Review showed scarce application of glycomics/metallomics despite great potential.
ISSN:0010-4825
1879-0534
DOI:10.1016/j.compbiomed.2021.105069