Aerobic exercise as a promising nonpharmacological therapy for the treatment of substance use disorders

Despite the prevalence and public health impact of substance use disorders (SUDs), effective long‐term treatments remain elusive. Aerobic exercise is a promising, nonpharmacological treatment currently under investigation as a strategy for preventing drug relapse. Aerobic exercise could be incorpora...

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Published in:Journal of neuroscience research 2022-08, Vol.100 (8), p.1602-1642
Main Authors: Marrero‐Cristobal, Gigliola, Gelpi‐Dominguez, Ursula, Morales‐Silva, Roberto, Alvarado‐Torres, John, Perez‐Torres, Joshua, Perez‐Perez, Yobet, Sepulveda‐Orengo, Marian
Format: Article
Language:English
Subjects:
Adaptation
alcohol
Animal models
Animals
cocaine
Disorders
Drug abuse
Drug-Seeking Behavior
exercise
Female
heroin and morphine
Humans
Male
methamphetamine
nicotine
Physiological effects
Public health
Rats
Recurrence
Substance use
Substance use disorder
Substance-Related Disorders - epidemiology
Substance-Related Disorders - therapy
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Summary:Despite the prevalence and public health impact of substance use disorders (SUDs), effective long‐term treatments remain elusive. Aerobic exercise is a promising, nonpharmacological treatment currently under investigation as a strategy for preventing drug relapse. Aerobic exercise could be incorporated into the comprehensive treatment regimens for people with substance abuse disorders. Preclinical studies of SUD with animal models have shown that aerobic exercise diminishes drug‐seeking behavior, which leads to relapse, in both male and female rats. Nevertheless, little is known regarding the effects of substance abuse‐induced cellular and physiological adaptations believed to be responsible for drug‐seeking behavior. Accordingly, the overall goal of this review is to provide a summary and an assessment of findings to date, highlighting evidence of the molecular and neurological effects of exercise on adaptations associated with SUD.
ISSN:0360-4012
1097-4547
1097-4547
DOI:10.1002/jnr.24990