Isoforms of autophagy-related proteins: role in glioma progression and therapy resistance

Autophagy is the process of recycling and utilization of degraded organelles and macromolecules in the cell compartments formed during the fusion of autophagosomes with lysosomes. During autophagy induction the healthy and tumor cells adapt themselves to harsh conditions such as cellular stress or i...

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Bibliographic Details
Published in:Molecular and cellular biochemistry 2022-02, Vol.477 (2), p.593-604
Main Authors: Belyaeva, Elizaveta, Kharwar, Rajesh Kumar, Ulasov, Ilya V., Karlina, Irina, Timashev, Petr, Mohammadinejad, Reza, Acharya, Arbind
Format: Article
Language:English
Subjects:
Antimitotic agents
Antineoplastic agents
Apoptosis
Autophagosomes - genetics
Autophagosomes - metabolism
Autophagy
Autophagy-Related Proteins - genetics
Autophagy-Related Proteins - metabolism
Biochemistry
Biomedical and Life Sciences
Brain tumors
Cardiology
Cell death
Cellular stress response
Development and progression
Glioma
Glioma - genetics
Glioma - metabolism
Glioma - therapy
Gliomas
Homeostasis
Humans
Isoforms
Life Sciences
Lysosomes
Macromolecules
Medical Biochemistry
Necroptosis
Neoplasm Proteins - metabolism
Nutrients
Oncology
Organelles
Phagosomes
Proteins
Tumor cells
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Summary:Autophagy is the process of recycling and utilization of degraded organelles and macromolecules in the cell compartments formed during the fusion of autophagosomes with lysosomes. During autophagy induction the healthy and tumor cells adapt themselves to harsh conditions such as cellular stress or insufficient supply of nutrients in the cell environment to maintain their homeostasis. Autophagy is currently seen as a form of programmed cell death along with apoptosis and necroptosis. In recent years multiple studies have considered the autophagy as a potential mechanism of anticancer therapy in malignant glioma. Although, subsequent steps in autophagy development are known and well-described, on molecular level the mechanism of autophagosome initiation and maturation using autophagy-related proteins is under investigation. This article reviews current state about the mechanism of autophagy, its molecular pathways and the most recent studies on roles of autophagy-related proteins and their isoforms in glioma progression and its treatment.
ISSN:0300-8177
1573-4919
DOI:10.1007/s11010-021-04308-w