Macular Telangiectasia type 2: multimodal assessment of retinal function and microstructure

Purpose To assess the impact of neurodegenerative morphologic alterations due to macular telangiectasia type 2 (MacTel) on microperimetry (MP) and multifocal electroretinography (mfERG). Methods Thirty‐five eyes of 18 patients with MacTel were examined using spectral domain optical coherence tomogra...

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Published in:Acta ophthalmologica (Oxford, England) England), 2022-09, Vol.100 (6), p.e1240-e1252
Main Authors: Ledolter, Anna A., Ristl, Robin, Palmowski‐Wolfe, Anja M., Montuoro, Alessio, Deak, Gabor G., Sacu, Stefan, Holder, Graham E., Schmidt‐Erfurth, Ursula, Ritter, Markus
Format: Article
Language:English
Subjects:
Electroretinograms
Eye
macular telangiectasia type 2
microperimetry
multifocal electroretinogram
Müller cells
Ophthalmology
Retina
Structure-function relationships
Tomography
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Summary:Purpose To assess the impact of neurodegenerative morphologic alterations due to macular telangiectasia type 2 (MacTel) on microperimetry (MP) and multifocal electroretinography (mfERG). Methods Thirty‐five eyes of 18 patients with MacTel were examined using spectral domain optical coherence tomography (SD‐OCT), fundus autofluorescence (FAF), mfERG and MP. Software was used to match SD‐OCT B‐scans with the corresponding retinal sensitivity map and multifocal electroretinograms (mfERGs), thus enabling direct structure/function correlation. Results Loss of the ellipsoid zone (EZ) had the strongest negative association with retinal sensitivity (16.77 dB versus 4.58 dB, adj. p 
ISSN:1755-375X
1755-3768
DOI:10.1111/aos.15072