The Influence of Water-Soluble Polysaccharides of Crataegus sanguinea Pall. on Nitric Oxide Production by Macrophages

The in vitro addition of water-soluble polysaccharides isolated from the leaves of Crataegus sanguinea Pall . to culture of mouse peritoneal macrophages induced classical activation of antigen-presenting cells by increasing NO synthase activity and reducing arginase expression.

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2021-12, Vol.172 (2), p.151-154
Main Authors: Ligacheva, A. A., Sherstoboev, E. Yu, Danilets, M. G., Trofimova, E. S., Krivoshchekov, S. V., Khasanova, S. R., Kudashkina, N. V., Gur’ev, A. M., Belousov, M. V.
Format: Article
Language:English
Subjects:
Animals
Antigen-presenting cells
Arginase
Arginase - drug effects
Arginase - metabolism
Biomedical and Life Sciences
Biomedicine
Cell activation
Cell Biology
Cell culture
Cells, Cultured
Crataegus - chemistry
Crataegus sanguinea
Female
Internal Medicine
Laboratory Medicine
Macrophages
Macrophages, Peritoneal - drug effects
Macrophages, Peritoneal - enzymology
Macrophages, Peritoneal - metabolism
Mice
Mice, Inbred C57BL
Nitric oxide
Nitric Oxide - metabolism
Nitric-oxide synthase
Pathology
Plant Extracts - chemistry
Plant Extracts - pharmacology
Plant Leaves - chemistry
Polysaccharides
Polysaccharides - isolation & purification
Polysaccharides - pharmacology
Solubility
Water - chemistry
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Description
Summary:The in vitro addition of water-soluble polysaccharides isolated from the leaves of Crataegus sanguinea Pall . to culture of mouse peritoneal macrophages induced classical activation of antigen-presenting cells by increasing NO synthase activity and reducing arginase expression.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-021-05353-7