Expression and Content of Protein LC3B in Gastric Cancer Tissue, Relationship with Expression of mTOR, AMPK in Gastric Cancer Tissue and HER2 and PD-L1 Status of the Tumor

• Published in: Bulletin of experimental biology and medicine 2021-12, Vol.172 (2), p.202-205
• Main Authors: Spirina, L. V., Avgustinovich, A. V., Afanas’ev, S. G., Volkov, M. Yu, Kondakova, I. V.
• Format: Article
• Language: English
• Subjects: Adenocarcinoma - diagnosis; Adenocarcinoma - drug therapy; Adenocarcinoma - genetics; Adenocarcinoma - metabolism; AMP-Activated Protein Kinases - genetics; AMP-Activated Protein Kinases - metabolism; Antineoplastic Agents - therapeutic use; B7-H1 Antigen - genetics; B7-H1 Antigen - metabolism; Biomarkers, Pharmacological - metabolism; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Biomedical and Life Sciences; Biomedicine; Cancer; Cell Biology; ErbB-2 protein; Ethylenediaminetetraacetic acid; Gastric cancer; Gene Expression Regulation, Neoplastic; Health aspects; Helicobacter infections; Humans; Internal Medicine; Laboratory Medicine; Metastasis; Microtubule-Associated Proteins - genetics; Microtubule-Associated Proteins - metabolism; mRNA; Pathology; PD-L1 protein; Prognosis; Receptor, ErbB-2 - genetics; Receptor, ErbB-2 - metabolism; RNA; Stomach cancer; Stomach Neoplasms - diagnosis; Stomach Neoplasms - drug therapy; Stomach Neoplasms - genetics; Stomach Neoplasms - metabolism; TOR protein; TOR Serine-Threonine Kinases - genetics; TOR Serine-Threonine Kinases - metabolism; Transformed cells; Treatment Outcome
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-021-05376-0

Analysis of HER2 status of the tumor and expression of mTOR, AMPK showed a decrease in mTOR mRNA level in HER2 + tumors in comparison with HER— status. The appearance of PD-L1 + transformed cells in the tumor was associated with increased expression of the LC3B gene and elevated content of the corresponding protein measured after treatment.