Development of fast-dissolving dosage forms of curcuminoids by electrospinning for potential tumor therapy application

[Display omitted] Curcuminoids (CUs) of antitumor and various other potential biological activities have extremely low water solubility therefore special formulation was elaborated. New fast dissolving reconstitution dosage forms of four CUs were prepared as fibrous form of 2-hydroxypropyl-β-cyclode...

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Published in:International journal of pharmaceutics 2022-01, Vol.611, p.121327-121327, Article 121327
Main Authors: Kiss, Krisztina, Hegedüs, Kristóf, Vass, Panna, Vári-Mező, Diána, Farkas, Attila, Nagy, Zsombor Kristóf, Molnár, László, Tóvári, József, Mező, Gábor, Marosi, György
Format: Article
Language:English
Subjects:
Aqueous electrospinning
Curcumin
Curcuminoids
Cyclodextrin
Diarylheptanoids
Excipients
Fast-dissolving
Humans
Hypromellose Derivatives
Neoplasms - drug therapy
Solubility
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Summary:[Display omitted] Curcuminoids (CUs) of antitumor and various other potential biological activities have extremely low water solubility therefore special formulation was elaborated. New fast dissolving reconstitution dosage forms of four CUs were prepared as fibrous form of 2-hydroxypropyl-β-cyclodextin (HP-β-CD). In the electrospinning process HP-β-CD could act both as solubilizer and fiber-forming agent. The solubilization efficiency of the CU-HP-β-CD systems was determined with phase-solubility measurements. The electrospun CUs were amorphous and uniformly distributed in the fibers according to XRD analysis and Raman mappings. The fibrous final products had fast (
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2021.121327