Fast dissolving nanofiber mat for the local antimicrobial application of roxithromycin in oral cavity

• Published in: Materials Science & Engineering C 2021-12, Vol.131, p.112537-112537, Article 112537
• Main Authors: Kim, Sungyun, Kim, Jung-Jin, Jeong, Jae-Hyeon, Kim, Yonghoon, Park, JiHye, Jeong, Da In, Kim, Hyun Jin, Hwang, ChaeRim, Ahn, Sung-Hoon, Ko, Hyun-Jeong, Cho, Hyun-Jong
• Format: Article
• Language: English
• Subjects: Amorphization; Antiinfectives and antibacterials; Antimicrobial application; Bacteria; Cyclodextrins; Disintegration; Dissolution; Drug delivery; Drug delivery systems; E coli; Electrospinning; Fast dissolving; Gram-negative bacteria; Gram-positive bacteria; Inclusion complexes; Infections; Materials science; Nanofiber; Nanofibers; Oral cavity; Polyethylene glycol; Polyvinyl alcohol; Respiratory tract; Respiratory tract diseases; Roxithromycin; Solubility; Wetting; β-Cyclodextrin
• ISSN: 0928-4931; 1873-0191
• DOI: 10.1016/j.msec.2021.112537

Fast disintegrating and dissolving nanofiber (NF) mat was devised to deliver roxithromycin for the treatment of the respiratory tract infection. NF membrane was made by an electrospinning process with poly(vinyl alcohol) (PVA), hydroxypropyl-β-cyclodextrin (HP-β-CD), and d-α-tocopheryl polyethylene glycol succinate (TPGS) for local application of roxithromycin. Roxithromycin has a poor water solubility thus HP-β-CD is introduced for enhancing drug solubility by forming an inclusion complex in this study. The addition of TPGS provided multiple roles such as accelerating wetting, disintegration, and dissolution speed and overcoming bacterial resistance. Roxithromycin was successfully entrapped in NF structure and drug amorphization occurred during the electrospinning process. PVA/HP-β-CD/TPGS/roxithromycin (PHTR) NF exhibited faster wetting, disintegration, and dissolution speed rather than the other NF mats. PHTR NF displayed higher antibacterial potentials in Gram-negative bacteria (E. coli) and Gram-positive bacteria (S. aureus) compared to other NF mat formulations. The administration of PHTR NF to oral cavity in pneumococcal disease mouse model provided the most efficient therapeutic potentials in lung tissue. Designed multiple phase-based NF mat may be one of powerful local drug delivery systems for the therapy of respiratory tract infection. •Fast dissolving nanofiber mat was developed for local delivery of roxithromycin.•Roxithromycin-loaded nanofiber mat was immediately wetted and disintegrated.•Nanofiber mat displayed sufficient antibacterial potentials to E. coli and S. aureus.