Employing of Fe3O4/CuO/ZnO@MWCNT MNCs in the solvent-free synthesis of new cyanopyrroloazepine derivatives and investigation of biological activity

In this research, we synthesized the Fe 3 O 4 /CuO/ZnO@MWCNT magnetic nanocomposites using water extract of Petasites hybridus rhizome, and the high performance of synthesized catalyst was confirmed by using in the solvent-free multicomponent reactions of isatoic anhydride, N -methylimidazole, alkyl...

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Published in:Molecular diversity 2022-08, Vol.26 (4), p.2121-2134
Main Authors: Zare Davijani, Neda, Kia-Kojoori, Reza, Abdolmohammadi, Shahrzad, Sadegh-Samiei, Sepehr
Format: Article
Language:English
Subjects:
Antioxidants
Biochemistry
Biological activity
Biomedical and Life Sciences
Investigations
Life Sciences
Metal oxides
Nanoparticles
Organic Chemistry
Original Article
Pharmacy
Polymer Sciences
Solvents
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Summary:In this research, we synthesized the Fe 3 O 4 /CuO/ZnO@MWCNT magnetic nanocomposites using water extract of Petasites hybridus rhizome, and the high performance of synthesized catalyst was confirmed by using in the solvent-free multicomponent reactions of isatoic anhydride, N -methylimidazole, alkyl bromides, activated acetylenic compounds and 2-aminoacetonitrile at ambient temperature for the production of new cyanopyrroloazepine derivatives in high yields. This catalyst could be used several times in these reactions and have main role in the yield of product. The synthesized cyanopyrroloazepines have NH groups in their structure and for this reason have good antioxidant activity. Also, employing Gram-positive and Gram-negative bacteria in the disk diffusion procedure confirmed some cyanopyrroloazepines antimicrobial effect. The results showed that synthesized cyanopyrroloazepine prevented the bacterial growth. This used process for preparation of new cyanopyrroloazepine has some improvements such as low reaction time, product with high yields, simple separation of catalyst and products. Graphic abstract
ISSN:1381-1991
1573-501X
DOI:10.1007/s11030-021-10319-y