Focus on ferroptosis, pyroptosis, apoptosis and autophagy of vascular endothelial cells to the strategic targets for the treatment of atherosclerosis

Vascular endothelial cells (VECs), which are lined up in the inner surface of blood vessels, are in direct contact with the metabolite-related endogenous danger signals in the circulatory system. Moreover, VECs death impairs vasodilation and increases endothelium-dependent permeability, which is str...

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Bibliographic Details
Published in:Archives of biochemistry and biophysics 2022-01, Vol.715, p.109098-109098, Article 109098
Main Authors: Lin, Xiaoyan, Ouyang, Siyu, Zhi, Chenxi, Li, Pin, Tan, Xiaoqian, Ma, Wentao, Yu, Jiang, Peng, Tianhong, Chen, Xi, Li, Liang, Xie, Wei
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Apoptosis - drug effects
Apoptosis - physiology
Atherosclerosis
Atherosclerosis - drug therapy
Atherosclerosis - physiopathology
Autophagy
Autophagy - drug effects
Autophagy - physiology
Endothelial Cells - drug effects
Endothelial Cells - metabolism
Ferroptosis
Ferroptosis - drug effects
Ferroptosis - physiology
Humans
Pyroptosis
Pyroptosis - drug effects
Pyroptosis - physiology
Vascular endothelial cells
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Summary:Vascular endothelial cells (VECs), which are lined up in the inner surface of blood vessels, are in direct contact with the metabolite-related endogenous danger signals in the circulatory system. Moreover, VECs death impairs vasodilation and increases endothelium-dependent permeability, which is strongly correlated with the development of atherosclerosis (AS). Among several forms of cell death, regulatory death of endothelial cells frequently occurs in AS, mainly including ferroptosis, pyroptosis, apoptosis and autophagy. In this review, we summarize regulatory factors and signaling mechanisms of regulatory death in endothelial cells, discussing their effects in the context of the atherosclerotic procession.
ISSN:0003-9861
1096-0384
DOI:10.1016/j.abb.2021.109098