Perfect adaptation of CD8 + T cell responses to constant antigen input over a wide range of affinities is overcome by costimulation

Reduced T cell responses by contrast antigen stimulation can be rescued by signals from costimulatory receptors.

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Bibliographic Details
Published in:Science signaling 2021-01, Vol.14 (666), p.eaay9363-eaay9363
Main Authors: Trendel, Nicola, Kruger, Philipp, Gaglione, Stephanie, Nguyen, John, Pettmann, Johannes, Sontag, Eduardo D, Dushek, Omer
Format: Article
Language:English
Subjects:
Adaptation
Affinity
Antigens
Autoantigens
CD28 antigen
CD8 antigen
CD8-Positive T-Lymphocytes
Cell activation
Cell surface
Cellular manufacture
Chimeric antigen receptors
Cytokines
Down-regulation
Immunological tolerance
Inactivation
Lymphocyte Activation
Lymphocytes
Lymphocytes T
Major histocompatibility complex
Receptors
Signaling
Stimulation
T cell receptors
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Description
Summary:Reduced T cell responses by contrast antigen stimulation can be rescued by signals from costimulatory receptors.
ISSN:1945-0877
1937-9145
DOI:10.1126/scisignal.aay9363