Loading…
Perfect adaptation of CD8 + T cell responses to constant antigen input over a wide range of affinities is overcome by costimulation
Reduced T cell responses by contrast antigen stimulation can be rescued by signals from costimulatory receptors.
Saved in:
| Published in: | Science signaling 2021-01, Vol.14 (666), p.eaay9363-eaay9363 |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c302t-88cdc066402e5030281dbe3d06b849e410db38e9e722706e25a4f10be60958ab3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c302t-88cdc066402e5030281dbe3d06b849e410db38e9e722706e25a4f10be60958ab3 |
| container_end_page | eaay9363 |
| container_issue | 666 |
| container_start_page | eaay9363 |
| container_title | Science signaling |
| container_volume | 14 |
| creator | Trendel, Nicola Kruger, Philipp Gaglione, Stephanie Nguyen, John Pettmann, Johannes Sontag, Eduardo D Dushek, Omer |
| description | Reduced T cell responses by contrast antigen stimulation can be rescued by signals from costimulatory receptors. |
| doi_str_mv | 10.1126/scisignal.aay9363 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2606933438</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2606933438</sourcerecordid><originalsourceid>FETCH-LOGICAL-c302t-88cdc066402e5030281dbe3d06b849e410db38e9e722706e25a4f10be60958ab3</originalsourceid><addsrcrecordid>eNpdkU1r3DAQhkVpaDZpf0AuQdBLIXirL8vyMWzzBYHkkJ6NLI8XBVtyJLllz_nj0W42e8hphuF532HmReiMkiWlTP6Oxka7dnpYar2pueRf0ILWvCpqKsqv216UBVFVdYxOYnwmRFLG6m_omAtVlqJiC_T6CKEHk7Du9JR0st5h3-PVH4Uv8BM2MAw4QJy8ixBx8tjkLmmXBS7ZNThs3TQn7P9BwBr_tx3goN0ati66762zyWaljTvE-BFwu8kuMdlxHnYLv6OjXg8RfuzrKfp7ffW0ui3uH27uVpf3heGEpUIp0xkipSAMSpJHinYt8I7IVokaBCVdyxXUUDFWEQms1KKnpAVJ6lLplp-iX---U_AvM8TUjDZuL9QO_BwbJomsORdcZfTnJ_TZzyF_OlNCUUalECRT9J0ywccYoG-mYEcdNg0lzTah5pBQs08oa873znM7QndQfETC3wBFEI_k</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2481216440</pqid></control><display><type>article</type><title>Perfect adaptation of CD8 + T cell responses to constant antigen input over a wide range of affinities is overcome by costimulation</title><source>Alma/SFX Local Collection</source><creator>Trendel, Nicola ; Kruger, Philipp ; Gaglione, Stephanie ; Nguyen, John ; Pettmann, Johannes ; Sontag, Eduardo D ; Dushek, Omer</creator><creatorcontrib>Trendel, Nicola ; Kruger, Philipp ; Gaglione, Stephanie ; Nguyen, John ; Pettmann, Johannes ; Sontag, Eduardo D ; Dushek, Omer</creatorcontrib><description>Reduced T cell responses by contrast antigen stimulation can be rescued by signals from costimulatory receptors.</description><identifier>ISSN: 1945-0877</identifier><identifier>EISSN: 1937-9145</identifier><identifier>DOI: 10.1126/scisignal.aay9363</identifier><identifier>PMID: 34855472</identifier><language>eng</language><publisher>United States: The American Association for the Advancement of Science</publisher><subject>Adaptation ; Affinity ; Antigens ; Autoantigens ; CD28 antigen ; CD8 antigen ; CD8-Positive T-Lymphocytes ; Cell activation ; Cell surface ; Cellular manufacture ; Chimeric antigen receptors ; Cytokines ; Down-regulation ; Immunological tolerance ; Inactivation ; Lymphocyte Activation ; Lymphocytes ; Lymphocytes T ; Major histocompatibility complex ; Receptors ; Signaling ; Stimulation ; T cell receptors</subject><ispartof>Science signaling, 2021-01, Vol.14 (666), p.eaay9363-eaay9363</ispartof><rights>Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c302t-88cdc066402e5030281dbe3d06b849e410db38e9e722706e25a4f10be60958ab3</citedby><cites>FETCH-LOGICAL-c302t-88cdc066402e5030281dbe3d06b849e410db38e9e722706e25a4f10be60958ab3</cites><orcidid>0000-0003-2776-0117 ; 0000-0001-5847-5226 ; 0000-0002-8078-5068 ; 0000-0002-4067-0178 ; 0000-0001-8020-5783</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34855472$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Trendel, Nicola</creatorcontrib><creatorcontrib>Kruger, Philipp</creatorcontrib><creatorcontrib>Gaglione, Stephanie</creatorcontrib><creatorcontrib>Nguyen, John</creatorcontrib><creatorcontrib>Pettmann, Johannes</creatorcontrib><creatorcontrib>Sontag, Eduardo D</creatorcontrib><creatorcontrib>Dushek, Omer</creatorcontrib><title>Perfect adaptation of CD8 + T cell responses to constant antigen input over a wide range of affinities is overcome by costimulation</title><title>Science signaling</title><addtitle>Sci Signal</addtitle><description>Reduced T cell responses by contrast antigen stimulation can be rescued by signals from costimulatory receptors.</description><subject>Adaptation</subject><subject>Affinity</subject><subject>Antigens</subject><subject>Autoantigens</subject><subject>CD28 antigen</subject><subject>CD8 antigen</subject><subject>CD8-Positive T-Lymphocytes</subject><subject>Cell activation</subject><subject>Cell surface</subject><subject>Cellular manufacture</subject><subject>Chimeric antigen receptors</subject><subject>Cytokines</subject><subject>Down-regulation</subject><subject>Immunological tolerance</subject><subject>Inactivation</subject><subject>Lymphocyte Activation</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Major histocompatibility complex</subject><subject>Receptors</subject><subject>Signaling</subject><subject>Stimulation</subject><subject>T cell receptors</subject><issn>1945-0877</issn><issn>1937-9145</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNpdkU1r3DAQhkVpaDZpf0AuQdBLIXirL8vyMWzzBYHkkJ6NLI8XBVtyJLllz_nj0W42e8hphuF532HmReiMkiWlTP6Oxka7dnpYar2pueRf0ILWvCpqKsqv216UBVFVdYxOYnwmRFLG6m_omAtVlqJiC_T6CKEHk7Du9JR0st5h3-PVH4Uv8BM2MAw4QJy8ixBx8tjkLmmXBS7ZNThs3TQn7P9BwBr_tx3goN0ati66762zyWaljTvE-BFwu8kuMdlxHnYLv6OjXg8RfuzrKfp7ffW0ui3uH27uVpf3heGEpUIp0xkipSAMSpJHinYt8I7IVokaBCVdyxXUUDFWEQms1KKnpAVJ6lLplp-iX---U_AvM8TUjDZuL9QO_BwbJomsORdcZfTnJ_TZzyF_OlNCUUalECRT9J0ywccYoG-mYEcdNg0lzTah5pBQs08oa873znM7QndQfETC3wBFEI_k</recordid><startdate>20210119</startdate><enddate>20210119</enddate><creator>Trendel, Nicola</creator><creator>Kruger, Philipp</creator><creator>Gaglione, Stephanie</creator><creator>Nguyen, John</creator><creator>Pettmann, Johannes</creator><creator>Sontag, Eduardo D</creator><creator>Dushek, Omer</creator><general>The American Association for the Advancement of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>JQ2</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2776-0117</orcidid><orcidid>https://orcid.org/0000-0001-5847-5226</orcidid><orcidid>https://orcid.org/0000-0002-8078-5068</orcidid><orcidid>https://orcid.org/0000-0002-4067-0178</orcidid><orcidid>https://orcid.org/0000-0001-8020-5783</orcidid></search><sort><creationdate>20210119</creationdate><title>Perfect adaptation of CD8 + T cell responses to constant antigen input over a wide range of affinities is overcome by costimulation</title><author>Trendel, Nicola ; Kruger, Philipp ; Gaglione, Stephanie ; Nguyen, John ; Pettmann, Johannes ; Sontag, Eduardo D ; Dushek, Omer</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c302t-88cdc066402e5030281dbe3d06b849e410db38e9e722706e25a4f10be60958ab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adaptation</topic><topic>Affinity</topic><topic>Antigens</topic><topic>Autoantigens</topic><topic>CD28 antigen</topic><topic>CD8 antigen</topic><topic>CD8-Positive T-Lymphocytes</topic><topic>Cell activation</topic><topic>Cell surface</topic><topic>Cellular manufacture</topic><topic>Chimeric antigen receptors</topic><topic>Cytokines</topic><topic>Down-regulation</topic><topic>Immunological tolerance</topic><topic>Inactivation</topic><topic>Lymphocyte Activation</topic><topic>Lymphocytes</topic><topic>Lymphocytes T</topic><topic>Major histocompatibility complex</topic><topic>Receptors</topic><topic>Signaling</topic><topic>Stimulation</topic><topic>T cell receptors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Trendel, Nicola</creatorcontrib><creatorcontrib>Kruger, Philipp</creatorcontrib><creatorcontrib>Gaglione, Stephanie</creatorcontrib><creatorcontrib>Nguyen, John</creatorcontrib><creatorcontrib>Pettmann, Johannes</creatorcontrib><creatorcontrib>Sontag, Eduardo D</creatorcontrib><creatorcontrib>Dushek, Omer</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Science signaling</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Trendel, Nicola</au><au>Kruger, Philipp</au><au>Gaglione, Stephanie</au><au>Nguyen, John</au><au>Pettmann, Johannes</au><au>Sontag, Eduardo D</au><au>Dushek, Omer</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Perfect adaptation of CD8 + T cell responses to constant antigen input over a wide range of affinities is overcome by costimulation</atitle><jtitle>Science signaling</jtitle><addtitle>Sci Signal</addtitle><date>2021-01-19</date><risdate>2021</risdate><volume>14</volume><issue>666</issue><spage>eaay9363</spage><epage>eaay9363</epage><pages>eaay9363-eaay9363</pages><issn>1945-0877</issn><eissn>1937-9145</eissn><abstract>Reduced T cell responses by contrast antigen stimulation can be rescued by signals from costimulatory receptors.</abstract><cop>United States</cop><pub>The American Association for the Advancement of Science</pub><pmid>34855472</pmid><doi>10.1126/scisignal.aay9363</doi><orcidid>https://orcid.org/0000-0003-2776-0117</orcidid><orcidid>https://orcid.org/0000-0001-5847-5226</orcidid><orcidid>https://orcid.org/0000-0002-8078-5068</orcidid><orcidid>https://orcid.org/0000-0002-4067-0178</orcidid><orcidid>https://orcid.org/0000-0001-8020-5783</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1945-0877 |
| ispartof | Science signaling, 2021-01, Vol.14 (666), p.eaay9363-eaay9363 |
| issn | 1945-0877 1937-9145 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2606933438 |
| source | Alma/SFX Local Collection |
| subjects | Adaptation Affinity Antigens Autoantigens CD28 antigen CD8 antigen CD8-Positive T-Lymphocytes Cell activation Cell surface Cellular manufacture Chimeric antigen receptors Cytokines Down-regulation Immunological tolerance Inactivation Lymphocyte Activation Lymphocytes Lymphocytes T Major histocompatibility complex Receptors Signaling Stimulation T cell receptors |
| title | Perfect adaptation of CD8 + T cell responses to constant antigen input over a wide range of affinities is overcome by costimulation |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T12%3A46%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Perfect%20adaptation%20of%20CD8%20+%20T%20cell%20responses%20to%20constant%20antigen%20input%20over%20a%20wide%20range%20of%20affinities%20is%20overcome%20by%20costimulation&rft.jtitle=Science%20signaling&rft.au=Trendel,%20Nicola&rft.date=2021-01-19&rft.volume=14&rft.issue=666&rft.spage=eaay9363&rft.epage=eaay9363&rft.pages=eaay9363-eaay9363&rft.issn=1945-0877&rft.eissn=1937-9145&rft_id=info:doi/10.1126/scisignal.aay9363&rft_dat=%3Cproquest_cross%3E2606933438%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c302t-88cdc066402e5030281dbe3d06b849e410db38e9e722706e25a4f10be60958ab3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2481216440&rft_id=info:pmid/34855472&rfr_iscdi=true |