The relationship between MFN1 copy number variation and growth traits of beef cattle

Copy number variation, as a kind of genetic submicroscopic structural variation, refers to the deletion or repetition of a large segment of genomic DNA, involving a segment size ranging from 50 bp to several MB. Mitochondrial fusion protein (MFN1) gene regulates the fusion of mitochondrial outer mem...

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Published in:Gene 2022-02, Vol.811, p.146071-146071, Article 146071
Main Authors: Yao, Zhi, Li, Jiaxiao, Zhang, Zijing, Chai, Yanan, Liu, Xian, Li, Jungang, Huang, Yajun, Li, Lijuan, Huang, Weihong, Yang, Guojie, Chen, Fuying, Shi, Qiaoting, Ru, Baorui, Lei, Chuzhao, Wang, Eryao, Huang, Yongzhen
Format: Article
Language:English
Subjects:
Animals
Association analysis
Body Weight - genetics
Bone Morphogenetic Proteins - genetics
Cattle
Cattle - genetics
Cattle - growth & development
CNV
DNA Copy Number Variations
Genetic Association Studies
Genetic Markers
Genetic Variation
Genotype
Growth traits
MFN1
Mitochondria
Mitochondria - physiology
Mitochondrial Membrane Transport Proteins - genetics
Mitochondrial Membrane Transport Proteins - metabolism
Phenotype
Polymorphism, Single Nucleotide
Quantitative Trait, Heritable
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Summary:Copy number variation, as a kind of genetic submicroscopic structural variation, refers to the deletion or repetition of a large segment of genomic DNA, involving a segment size ranging from 50 bp to several MB. Mitochondrial fusion protein (MFN1) gene regulates the fusion of mitochondrial outer membrane in cells and maintains the dynamic needs of reticular mitochondria in cells. In this study, we conducted to tested the dstribution characteristics of MFN1-CNV in 522 cattles across Xianan cattle (XN), Pinan cattle (PN), Qinchuan cattle (QC), Jiaxian cattle (JX), Yunling cattle (YL), and correlated it with phenotypic traits. Then we observed the expression of MFN1 in various tissues of QC cattle (n = 3), and the expression levels were higher in lung and muscle. The results showed that there was significant correlation between MFN1 gene CNV and hucklebone width of QC cattle, hip width and height at sacrum of JX red cattle, chest width and rump length of YL cattle (P 
ISSN:0378-1119
1879-0038
DOI:10.1016/j.gene.2021.146071