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Influence of diabetes mellitus interactions with cardiovascular risk factors on post-myocardial infarction heart failure hospitalizations
There is a paucity of information regarding how cardiovascular risk factors (RF) modulate the impact of diabetes mellitus (DM) on the heart failure hospitalization (HFH) risk following an acute myocardial infarction (AMI). Adult survivors of an AMI were retrospectively identified from the 2014 US Na...
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| Published in: | International journal of cardiology 2022-02, Vol.348, p.140-146 |
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| container_end_page | 146 |
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| container_start_page | 140 |
| container_title | International journal of cardiology |
| container_volume | 348 |
| creator | Yandrapalli, Srikanth Malik, Aaqib H. Namrata, Fnu Pemmasani, Gayatri Bandyopadhyay, Dhrubajyoti Vallabhajosyula, Saraschandra Aronow, Wilbert S. Frishman, William H. Jain, Diwakar Cooper, Howard A. Panza, Julio A. |
| description | There is a paucity of information regarding how cardiovascular risk factors (RF) modulate the impact of diabetes mellitus (DM) on the heart failure hospitalization (HFH) risk following an acute myocardial infarction (AMI).
Adult survivors of an AMI were retrospectively identified from the 2014 US Nationwide Readmissions Database. The impact of DM on the risk for a 6-month HFH was studied in subgroups of RFs using multivariable logistic regression to adjust for baseline risk differences. Individual interactions of DM with RFs were tested.
Of 237,549 AMI survivors, 37.2% patients had DM. Primary outcome occurred in 12,934 patients (5.4%), at a 106% higher rate in DM patients (7.9% vs 4.0%, p |
| doi_str_mv | 10.1016/j.ijcard.2021.11.086 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2607307685</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0167527321019768</els_id><sourcerecordid>2607307685</sourcerecordid><originalsourceid>FETCH-LOGICAL-c362t-366feb806042ae3120e51280619e4be7055523fb3dbac3abfa61cc76c536e3f43</originalsourceid><addsrcrecordid>eNp9kU9v1DAQxS0EotvCN0DIRy4J_p_sBQlVBSpV4gJna-KMtV6SeLGdovIN-NZ4d1uOnEYj_d57mnmEvOGs5Yyb9_s27B2ksRVM8JbzlvXmGdnwvlMN77R6TjYV6xotOnlBLnPeM8bUdtu_JBdS9UaxXm_In9vFTysuDmn0dAwwYMFMZ5ymUNZMw1IwgSshLpn-CmVHj5kh3kN26wSJppB_UF-JmDKNCz3EXJr5IZ4wmKqBh3TS0x1CKpUN05qQ7mI-hAJT-A0n91fkhYcp4-vHeUW-f7r5dv2lufv6-fb6413jpBGlkcZ4HHpmmBKAkguGmou68y2qATumtRbSD3IcwEkYPBjuXGeclgalV_KKvDv7HlL8uWIudg7Z1XthwbhmKwzrJOtMryuqzqhLMeeE3h5SmCE9WM7ssQS7t-cS7LEEy7mtJVTZ28eEdZhx_Cd6-noFPpwBrHfeB0w2u3DsYAwJXbFjDP9P-AtyOJ5d</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2607307685</pqid></control><display><type>article</type><title>Influence of diabetes mellitus interactions with cardiovascular risk factors on post-myocardial infarction heart failure hospitalizations</title><source>Elsevier:Jisc Collections:Elsevier Read and Publish Agreement 2022-2024:Freedom Collection (Reading list)</source><creator>Yandrapalli, Srikanth ; Malik, Aaqib H. ; Namrata, Fnu ; Pemmasani, Gayatri ; Bandyopadhyay, Dhrubajyoti ; Vallabhajosyula, Saraschandra ; Aronow, Wilbert S. ; Frishman, William H. ; Jain, Diwakar ; Cooper, Howard A. ; Panza, Julio A.</creator><creatorcontrib>Yandrapalli, Srikanth ; Malik, Aaqib H. ; Namrata, Fnu ; Pemmasani, Gayatri ; Bandyopadhyay, Dhrubajyoti ; Vallabhajosyula, Saraschandra ; Aronow, Wilbert S. ; Frishman, William H. ; Jain, Diwakar ; Cooper, Howard A. ; Panza, Julio A.</creatorcontrib><description>There is a paucity of information regarding how cardiovascular risk factors (RF) modulate the impact of diabetes mellitus (DM) on the heart failure hospitalization (HFH) risk following an acute myocardial infarction (AMI).
Adult survivors of an AMI were retrospectively identified from the 2014 US Nationwide Readmissions Database. The impact of DM on the risk for a 6-month HFH was studied in subgroups of RFs using multivariable logistic regression to adjust for baseline risk differences. Individual interactions of DM with RFs were tested.
Of 237,549 AMI survivors, 37.2% patients had DM. Primary outcome occurred in 12,934 patients (5.4%), at a 106% higher rate in DM patients (7.9% vs 4.0%, p < 0.001), which was attenuated to a 45% higher adjusted risk. Higher HFH risk in DM patients was consistent across subgroups and significant interactions were present between DM and other RFs. The increased HFH risk with DM was more pronounced in patients without certain HF RFs compared with those with these RFs [age < 65: OR for DM 1.84 (1.58–2.13) vs age ≥ 65: OR 1.34 (1.24–1.45); HF absent during index AMI: OR for DM 1.87 (1.66–2.10) vs HF present: OR 1.24 (1.14–1.34); atrial fibrillation absent: OR for DM 1.57 (1.46–1.68) vs present: OR 1.19 (1.06–1.33); Pinteraction < 0.001 for all]. Similar results were noted for hypertension and chronic kidney disease.
AMI survivors with DM had a higher risk of 6-month HFHs. The impact of DM on the increased HFH risk was more pronounced in patients without certain RFs suggesting that more aggressive preventive strategies related to DM and HF are needed in these subgroups to prevent or delay the onset of HFHs.
•Patients with diabetes mellitus were more likely to have adverse heart failure-related outcomes in the subsequent 6 months following an acute myocardial infarction.•Higher heart failure admission risk with diabetes was consistent across subgroups of age and major cardiac risk factors.•The impact of diabetes on post-myocardial infarction heart failure admission risk was higher in patients without certain important heart failure risk factors.•Understanding the differential impact of diabetes mellitus on heart failure risk among clinically relevant subgroups should prompt investigations of strategies to mitigate or delay the HF risk.•Patient groups with higher heart failure risk attribution from diabetes might benefit from aggressive therapy and follow up to delay the onset of heart failure requiring hospitalization.</description><identifier>ISSN: 0167-5273</identifier><identifier>EISSN: 1874-1754</identifier><identifier>DOI: 10.1016/j.ijcard.2021.11.086</identifier><identifier>PMID: 34864085</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Acute myocardial infarction ; Adult ; Cardiovascular Diseases ; Diabetes mellitus ; Diabetes Mellitus - diagnosis ; Diabetes Mellitus - epidemiology ; Heart Disease Risk Factors ; Heart failure ; Heart Failure - diagnosis ; Heart Failure - epidemiology ; Hospitalization ; Humans ; Myocardial Infarction - diagnosis ; Myocardial Infarction - epidemiology ; Outcomes ; Retrospective Studies ; Risk Factors</subject><ispartof>International journal of cardiology, 2022-02, Vol.348, p.140-146</ispartof><rights>2021</rights><rights>Copyright © 2021. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-366feb806042ae3120e51280619e4be7055523fb3dbac3abfa61cc76c536e3f43</citedby><cites>FETCH-LOGICAL-c362t-366feb806042ae3120e51280619e4be7055523fb3dbac3abfa61cc76c536e3f43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34864085$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yandrapalli, Srikanth</creatorcontrib><creatorcontrib>Malik, Aaqib H.</creatorcontrib><creatorcontrib>Namrata, Fnu</creatorcontrib><creatorcontrib>Pemmasani, Gayatri</creatorcontrib><creatorcontrib>Bandyopadhyay, Dhrubajyoti</creatorcontrib><creatorcontrib>Vallabhajosyula, Saraschandra</creatorcontrib><creatorcontrib>Aronow, Wilbert S.</creatorcontrib><creatorcontrib>Frishman, William H.</creatorcontrib><creatorcontrib>Jain, Diwakar</creatorcontrib><creatorcontrib>Cooper, Howard A.</creatorcontrib><creatorcontrib>Panza, Julio A.</creatorcontrib><title>Influence of diabetes mellitus interactions with cardiovascular risk factors on post-myocardial infarction heart failure hospitalizations</title><title>International journal of cardiology</title><addtitle>Int J Cardiol</addtitle><description>There is a paucity of information regarding how cardiovascular risk factors (RF) modulate the impact of diabetes mellitus (DM) on the heart failure hospitalization (HFH) risk following an acute myocardial infarction (AMI).
Adult survivors of an AMI were retrospectively identified from the 2014 US Nationwide Readmissions Database. The impact of DM on the risk for a 6-month HFH was studied in subgroups of RFs using multivariable logistic regression to adjust for baseline risk differences. Individual interactions of DM with RFs were tested.
Of 237,549 AMI survivors, 37.2% patients had DM. Primary outcome occurred in 12,934 patients (5.4%), at a 106% higher rate in DM patients (7.9% vs 4.0%, p < 0.001), which was attenuated to a 45% higher adjusted risk. Higher HFH risk in DM patients was consistent across subgroups and significant interactions were present between DM and other RFs. The increased HFH risk with DM was more pronounced in patients without certain HF RFs compared with those with these RFs [age < 65: OR for DM 1.84 (1.58–2.13) vs age ≥ 65: OR 1.34 (1.24–1.45); HF absent during index AMI: OR for DM 1.87 (1.66–2.10) vs HF present: OR 1.24 (1.14–1.34); atrial fibrillation absent: OR for DM 1.57 (1.46–1.68) vs present: OR 1.19 (1.06–1.33); Pinteraction < 0.001 for all]. Similar results were noted for hypertension and chronic kidney disease.
AMI survivors with DM had a higher risk of 6-month HFHs. The impact of DM on the increased HFH risk was more pronounced in patients without certain RFs suggesting that more aggressive preventive strategies related to DM and HF are needed in these subgroups to prevent or delay the onset of HFHs.
•Patients with diabetes mellitus were more likely to have adverse heart failure-related outcomes in the subsequent 6 months following an acute myocardial infarction.•Higher heart failure admission risk with diabetes was consistent across subgroups of age and major cardiac risk factors.•The impact of diabetes on post-myocardial infarction heart failure admission risk was higher in patients without certain important heart failure risk factors.•Understanding the differential impact of diabetes mellitus on heart failure risk among clinically relevant subgroups should prompt investigations of strategies to mitigate or delay the HF risk.•Patient groups with higher heart failure risk attribution from diabetes might benefit from aggressive therapy and follow up to delay the onset of heart failure requiring hospitalization.</description><subject>Acute myocardial infarction</subject><subject>Adult</subject><subject>Cardiovascular Diseases</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus - diagnosis</subject><subject>Diabetes Mellitus - epidemiology</subject><subject>Heart Disease Risk Factors</subject><subject>Heart failure</subject><subject>Heart Failure - diagnosis</subject><subject>Heart Failure - epidemiology</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Myocardial Infarction - diagnosis</subject><subject>Myocardial Infarction - epidemiology</subject><subject>Outcomes</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><issn>0167-5273</issn><issn>1874-1754</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kU9v1DAQxS0EotvCN0DIRy4J_p_sBQlVBSpV4gJna-KMtV6SeLGdovIN-NZ4d1uOnEYj_d57mnmEvOGs5Yyb9_s27B2ksRVM8JbzlvXmGdnwvlMN77R6TjYV6xotOnlBLnPeM8bUdtu_JBdS9UaxXm_In9vFTysuDmn0dAwwYMFMZ5ymUNZMw1IwgSshLpn-CmVHj5kh3kN26wSJppB_UF-JmDKNCz3EXJr5IZ4wmKqBh3TS0x1CKpUN05qQ7mI-hAJT-A0n91fkhYcp4-vHeUW-f7r5dv2lufv6-fb6413jpBGlkcZ4HHpmmBKAkguGmou68y2qATumtRbSD3IcwEkYPBjuXGeclgalV_KKvDv7HlL8uWIudg7Z1XthwbhmKwzrJOtMryuqzqhLMeeE3h5SmCE9WM7ssQS7t-cS7LEEy7mtJVTZ28eEdZhx_Cd6-noFPpwBrHfeB0w2u3DsYAwJXbFjDP9P-AtyOJ5d</recordid><startdate>20220201</startdate><enddate>20220201</enddate><creator>Yandrapalli, Srikanth</creator><creator>Malik, Aaqib H.</creator><creator>Namrata, Fnu</creator><creator>Pemmasani, Gayatri</creator><creator>Bandyopadhyay, Dhrubajyoti</creator><creator>Vallabhajosyula, Saraschandra</creator><creator>Aronow, Wilbert S.</creator><creator>Frishman, William H.</creator><creator>Jain, Diwakar</creator><creator>Cooper, Howard A.</creator><creator>Panza, Julio A.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20220201</creationdate><title>Influence of diabetes mellitus interactions with cardiovascular risk factors on post-myocardial infarction heart failure hospitalizations</title><author>Yandrapalli, Srikanth ; Malik, Aaqib H. ; Namrata, Fnu ; Pemmasani, Gayatri ; Bandyopadhyay, Dhrubajyoti ; Vallabhajosyula, Saraschandra ; Aronow, Wilbert S. ; Frishman, William H. ; Jain, Diwakar ; Cooper, Howard A. ; Panza, Julio A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-366feb806042ae3120e51280619e4be7055523fb3dbac3abfa61cc76c536e3f43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Acute myocardial infarction</topic><topic>Adult</topic><topic>Cardiovascular Diseases</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus - diagnosis</topic><topic>Diabetes Mellitus - epidemiology</topic><topic>Heart Disease Risk Factors</topic><topic>Heart failure</topic><topic>Heart Failure - diagnosis</topic><topic>Heart Failure - epidemiology</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Myocardial Infarction - diagnosis</topic><topic>Myocardial Infarction - epidemiology</topic><topic>Outcomes</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yandrapalli, Srikanth</creatorcontrib><creatorcontrib>Malik, Aaqib H.</creatorcontrib><creatorcontrib>Namrata, Fnu</creatorcontrib><creatorcontrib>Pemmasani, Gayatri</creatorcontrib><creatorcontrib>Bandyopadhyay, Dhrubajyoti</creatorcontrib><creatorcontrib>Vallabhajosyula, Saraschandra</creatorcontrib><creatorcontrib>Aronow, Wilbert S.</creatorcontrib><creatorcontrib>Frishman, William H.</creatorcontrib><creatorcontrib>Jain, Diwakar</creatorcontrib><creatorcontrib>Cooper, Howard A.</creatorcontrib><creatorcontrib>Panza, Julio A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yandrapalli, Srikanth</au><au>Malik, Aaqib H.</au><au>Namrata, Fnu</au><au>Pemmasani, Gayatri</au><au>Bandyopadhyay, Dhrubajyoti</au><au>Vallabhajosyula, Saraschandra</au><au>Aronow, Wilbert S.</au><au>Frishman, William H.</au><au>Jain, Diwakar</au><au>Cooper, Howard A.</au><au>Panza, Julio A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of diabetes mellitus interactions with cardiovascular risk factors on post-myocardial infarction heart failure hospitalizations</atitle><jtitle>International journal of cardiology</jtitle><addtitle>Int J Cardiol</addtitle><date>2022-02-01</date><risdate>2022</risdate><volume>348</volume><spage>140</spage><epage>146</epage><pages>140-146</pages><issn>0167-5273</issn><eissn>1874-1754</eissn><abstract>There is a paucity of information regarding how cardiovascular risk factors (RF) modulate the impact of diabetes mellitus (DM) on the heart failure hospitalization (HFH) risk following an acute myocardial infarction (AMI).
Adult survivors of an AMI were retrospectively identified from the 2014 US Nationwide Readmissions Database. The impact of DM on the risk for a 6-month HFH was studied in subgroups of RFs using multivariable logistic regression to adjust for baseline risk differences. Individual interactions of DM with RFs were tested.
Of 237,549 AMI survivors, 37.2% patients had DM. Primary outcome occurred in 12,934 patients (5.4%), at a 106% higher rate in DM patients (7.9% vs 4.0%, p < 0.001), which was attenuated to a 45% higher adjusted risk. Higher HFH risk in DM patients was consistent across subgroups and significant interactions were present between DM and other RFs. The increased HFH risk with DM was more pronounced in patients without certain HF RFs compared with those with these RFs [age < 65: OR for DM 1.84 (1.58–2.13) vs age ≥ 65: OR 1.34 (1.24–1.45); HF absent during index AMI: OR for DM 1.87 (1.66–2.10) vs HF present: OR 1.24 (1.14–1.34); atrial fibrillation absent: OR for DM 1.57 (1.46–1.68) vs present: OR 1.19 (1.06–1.33); Pinteraction < 0.001 for all]. Similar results were noted for hypertension and chronic kidney disease.
AMI survivors with DM had a higher risk of 6-month HFHs. The impact of DM on the increased HFH risk was more pronounced in patients without certain RFs suggesting that more aggressive preventive strategies related to DM and HF are needed in these subgroups to prevent or delay the onset of HFHs.
•Patients with diabetes mellitus were more likely to have adverse heart failure-related outcomes in the subsequent 6 months following an acute myocardial infarction.•Higher heart failure admission risk with diabetes was consistent across subgroups of age and major cardiac risk factors.•The impact of diabetes on post-myocardial infarction heart failure admission risk was higher in patients without certain important heart failure risk factors.•Understanding the differential impact of diabetes mellitus on heart failure risk among clinically relevant subgroups should prompt investigations of strategies to mitigate or delay the HF risk.•Patient groups with higher heart failure risk attribution from diabetes might benefit from aggressive therapy and follow up to delay the onset of heart failure requiring hospitalization.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>34864085</pmid><doi>10.1016/j.ijcard.2021.11.086</doi><tpages>7</tpages></addata></record> |
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| subjects | Acute myocardial infarction Adult Cardiovascular Diseases Diabetes mellitus Diabetes Mellitus - diagnosis Diabetes Mellitus - epidemiology Heart Disease Risk Factors Heart failure Heart Failure - diagnosis Heart Failure - epidemiology Hospitalization Humans Myocardial Infarction - diagnosis Myocardial Infarction - epidemiology Outcomes Retrospective Studies Risk Factors |
| title | Influence of diabetes mellitus interactions with cardiovascular risk factors on post-myocardial infarction heart failure hospitalizations |
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