Review of the diagnosis and treatment of brain metastases

Abstract Brain metastases (BM) occur in at least 10% of cancer patients, and are one of the main causes of cancer-related deaths and significant deterioration in the quality of life of cancer patients due to the neurological deterioration caused by brain compression and tumor invasion. Whole-brain i...

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Bibliographic Details
Published in:Japanese journal of clinical oncology 2022-01, Vol.52 (1), p.3-7
Main Authors: Narita, Yoshitaka, Sato, Shinya, Kayama, Takamasa
Format: Article
Language:English
Subjects:
Brain Neoplasms - surgery
Cranial Irradiation
Humans
Magnetic Resonance Imaging
Quality of Life
Radiosurgery
Retrospective Studies
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Summary:Abstract Brain metastases (BM) occur in at least 10% of cancer patients, and are one of the main causes of cancer-related deaths and significant deterioration in the quality of life of cancer patients due to the neurological deterioration caused by brain compression and tumor invasion. Whole-brain irradiation has been emphasized as the standard treatment for BM. However, recent clinical trials including the JLGK0901 and JCOG0504 trials conducted in Japan have established therapeutic evidence for the use of stereotactic radiosurgery with regular follow-up with magnetic resonance imaging for BM. In addition to surgery and stereotactic radiotherapy, advances in drug therapy for BM, such as tyrosine kinase inhibitors and immune checkpoint inhibitors, are expected. This review describes the history and the recent evidence of the diagnosis and treatment of BM. Recent clinical trials have established therapeutic evidence for the use of stereotactic radiosurgery with regular follow-up with magnetic resonance imaging for brain metastases.
ISSN:1465-3621
1465-3621
DOI:10.1093/jjco/hyab182