Factors contributing to CSF NfL reduction over time in those starting treatment for multiple sclerosis: an observational study

HIGHLIGHTS•An observational cohort study of 61 pwMS with two CSF NfL measurements as part of their routine follow-up. Forty pwMS were untreated at the first CSF sampling timepoint and treated at the second. •Factors reflecting early disease stage, including a younger age, lower disability and relaps...

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Published in:Multiple sclerosis and related disorders 2022-01, Vol.57, p.103409-103409, Article 103409
Main Authors: Smets, Ide, PhD, Holden, David, PhD, Bianchi, Lucia, PhD, Ammoscato, Francesca, PhD, Allen-Philbey, Kimberley, MSc, Baker, David, PhD, Turner, Benjamin, MD, Marta, Monica, PhD, Giovannoni, Gavin, PhD, Macdougall, Amy, Schmierer, Klaus, PhD, Hobart, Jeremy, PhD, Gnanapavan, Sharmilee, PhD
Format: Article
Language:English
Subjects:
Adult
Biomarkers
Cohort Studies
Humans
Magnetic Resonance Imaging
Middle Aged
Multiple sclerosis
Multiple Sclerosis - diagnostic imaging
Multiple Sclerosis - drug therapy
Neurology
Neurons
Treatment response
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Summary:HIGHLIGHTS•An observational cohort study of 61 pwMS with two CSF NfL measurements as part of their routine follow-up. Forty pwMS were untreated at the first CSF sampling timepoint and treated at the second. •Factors reflecting early disease stage, including a younger age, lower disability and relapsing MS were associated with treatment response in CSF NfL. •There was no association in CSF NfL reduction with BMI, disease duration, sex or lymphopenia in highly-active treatments.
ISSN:2211-0348
2211-0356
DOI:10.1016/j.msard.2021.103409