Development and validation of a nomogram for steroid-resistance prediction in immune thrombocytopenia patients

Corticosteroid is first-line therapy in immune thrombocytopenia. However, nearly 30% of patients appear in steroid-resistance. Our research analyses the relevant indicators of patients and develops a risk prediction model to predict the poor response to steroid-therapy in ITP patients. We collected...

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Bibliographic Details
Published in:Hematology (Luxembourg) 2021-01, Vol.26 (1), p.956-963
Main Authors: Yu, Jieni, Xu, Zhiqiang, Zhuo, Yuanyuan, Wei, Huahua, Ye, Yinhai, Xu, Qinhong, Li, Youli, Yu, Lihong, Feng, Weiying, Hong, Pan, Zhang, Kejie
Format: Article
Language:English
Subjects:
Adult
Age Factors
Drug Resistance
eltrombopag
Female
Ferritins - blood
hepatitis B virus
Humans
Immune thrombocytopenia
Male
Middle Aged
Nomograms
Purpura, Thrombocytopenic, Idiopathic - blood
Purpura, Thrombocytopenic, Idiopathic - drug therapy
Recurrence
response to therapy
ROC Curve
serum ferritin
steroid-refractory
Steroids - therapeutic use
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Summary:Corticosteroid is first-line therapy in immune thrombocytopenia. However, nearly 30% of patients appear in steroid-resistance. Our research analyses the relevant indicators of patients and develops a risk prediction model to predict the poor response to steroid-therapy in ITP patients. We collected data from 111 ITP patients admitted to Xiamen University Zhongshan Hospital from 2013 to 2019 as the training cohort and 65 ITP patients during 2019-2020 as the external validation cohort. Screening significant factors(P 16% and
ISSN:1607-8454
1607-8454
DOI:10.1080/16078454.2021.2003066