Tibial cortical and trabecular variables together can pinpoint the timing of impact loading relative to menarche in premenopausal females

Objectives Though relationships between limb bone structure and mechanical loading have provided fantastic opportunities for understanding the lives of prehistoric adults, the lives of children remain poorly understood. Our aim was to determine whether or not adult tibial skeletal variables retain i...

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Bibliographic Details
Published in:American journal of human biology 2022-08, Vol.34 (8), p.e23711-n/a
Main Authors: Murray, Alison A., Erlandson, Marta C.
Format: Article
Language:English
Subjects:
Adolescents
Athletes
Body mass
Bone mineral density
Cancellous bone
Children
Computed tomography
Cortical bone
Densitometers
Diaphysis
Epiphysis
Females
Impact loads
Load history
Mechanical loading
Menarche
Tibia
Young adults
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Summary:Objectives Though relationships between limb bone structure and mechanical loading have provided fantastic opportunities for understanding the lives of prehistoric adults, the lives of children remain poorly understood. Our aim was to determine whether or not adult tibial skeletal variables retain information about childhood/adolescent loading, through assessing relationships between cortical and trabecular bone variables and the timing of impact loading relative to menarche in premenopausal adult females. Methods Peripheral quantitative computed tomography was used to quantify geometric and densitometric variables from the proximal tibial diaphysis (66% location) and distal epiphysis (4% location) among 81 nulliparous young adult female controls and athletes aged 19–33 years grouped according to intensity of impact loading both pre‐ and post‐menarche: (1) Low:Low (Controls); (2) High:Low; (3) High:High; (4) Moderate:Moderate; (5) Low:Moderate. ANCOVA was used to compare properties among the groups adjusted for age, stature, and body mass. Results Significant increases in diaphyseal total cross‐sectional area and strength‐strain index were documented among groups with any pre‐menarcheal impact loading relative to groups with none, regardless of post‐menarcheal loading history (p 
ISSN:1042-0533
1520-6300
DOI:10.1002/ajhb.23711