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Detection of glioblastoma multiforme using quantitative molecular magnetic resonance imaging based on 5-aminolevulinic acid: in vitro and in vivo studies
Objectives We demonstrated a novel metabolic method based on sequential administration of 5-aminolevulinic acid (ALA) and iron supplement, and ferric ammonium citrate (FAC), for glioblastoma multiforme (GBM) detection using R 2 ’ and quantitative susceptibility mapping (QSM). Materials and methods I...
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| Published in: | Magma (New York, N.Y.) N.Y.), 2022-02, Vol.35 (1), p.3-15 |
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| container_title | Magma (New York, N.Y.) |
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| creator | Ebrahimpour, Anita Tirgar, Fatemeh Hajipour-Verdom, Behnam Abbasi, Ardeshir Hadjighassem, Mahmoudreza Abdolmaleki, Parviz Hosseindoost, Saereh Javadi, Seyed Amir Hossein Hashemi, Hassan Foroushani, Abbas Rahimi Alam, Nader Riyahi Khoobi, Mehdi |
| description | Objectives
We demonstrated a novel metabolic method based on sequential administration of 5-aminolevulinic acid (ALA) and iron supplement, and ferric ammonium citrate (FAC), for glioblastoma multiforme (GBM) detection using R
2
’ and quantitative susceptibility mapping (QSM).
Materials and methods
Intra-cellular iron accumulation in glioblastoma cells treated with ALA and/or FAC was measured. Cell phantoms containing glioblastoma cells and Wistar rats bearing C
6
glioblastoma were imaged using a 3 T MRI scanner after sequential administration of ALA and FAC. The relaxivity and QSM analysis were performed on the images.
Results
The intra-cellular iron deposition was significantly higher in the glioma cells with sequential treatment of ALA and FAC for 6 h compared to those treated with the controls. The relaxivity and magnetic susceptibility values of the glioblastoma cells and rat brain tumors treated with ALA + FAC (115 ± 5 s-1 for
R
2
’, and 0.1 ± 0.02 ppm for magnetic susceptibility) were significantly higher than those treated with the controls (55 ± 18 (FAC), 45 ± 15 (ALA) s-1 for
R
2
’,
p
|
| doi_str_mv | 10.1007/s10334-021-00978-1 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2608127944</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2608127944</sourcerecordid><originalsourceid>FETCH-LOGICAL-c347t-ed60e405d08a159f212da846a175d1ccddf0c47ea1922411b68ba740c44a2fc93</originalsourceid><addsrcrecordid>eNp9kc1u1TAQhS1ERS8tL8ACeckmYDtO4rBD5VeqxIaurYk9uXLl2K1_rsSj9G1xSWHJajQz3znSzCHkNWfvOGPT-8xZ38uOCd4xNk-q48_IgfeD6NQ48ufkwOZRdYOQ_Tl5mfMta-TA-hfkvJdqUiOfD-ThExY0xcVA40qP3sXFQy5xA7pVX9wa04a0ZheO9L5CKK5AcSekW_RoqodENzgGLM7QhDkGCAapa7NHxQIZLW3eQwebC01yqt6FxoJx9gN1gZ5cSZFCsHtzijSXah3mS3K2gs_46qlekJsvn39efeuuf3z9fvXxujO9nEqHdmQo2WCZAj7Mq-DCgpIj8Gmw3BhrV2bkhMBnISTny6gWmGSbSRCrmfsL8nb3vUvxvmIuenPZoPcQMNasxcgUF9MsZUPFjpoUc0646rvUTk2_NGf6MRK9R6Lbo_WfSDRvojdP_nXZ0P6T_M2gAf0O5LYKR0z6NtYU2s3_s_0NnXWapA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2608127944</pqid></control><display><type>article</type><title>Detection of glioblastoma multiforme using quantitative molecular magnetic resonance imaging based on 5-aminolevulinic acid: in vitro and in vivo studies</title><source>Springer Nature</source><creator>Ebrahimpour, Anita ; Tirgar, Fatemeh ; Hajipour-Verdom, Behnam ; Abbasi, Ardeshir ; Hadjighassem, Mahmoudreza ; Abdolmaleki, Parviz ; Hosseindoost, Saereh ; Javadi, Seyed Amir Hossein ; Hashemi, Hassan ; Foroushani, Abbas Rahimi ; Alam, Nader Riyahi ; Khoobi, Mehdi</creator><creatorcontrib>Ebrahimpour, Anita ; Tirgar, Fatemeh ; Hajipour-Verdom, Behnam ; Abbasi, Ardeshir ; Hadjighassem, Mahmoudreza ; Abdolmaleki, Parviz ; Hosseindoost, Saereh ; Javadi, Seyed Amir Hossein ; Hashemi, Hassan ; Foroushani, Abbas Rahimi ; Alam, Nader Riyahi ; Khoobi, Mehdi</creatorcontrib><description>Objectives
We demonstrated a novel metabolic method based on sequential administration of 5-aminolevulinic acid (ALA) and iron supplement, and ferric ammonium citrate (FAC), for glioblastoma multiforme (GBM) detection using R
2
’ and quantitative susceptibility mapping (QSM).
Materials and methods
Intra-cellular iron accumulation in glioblastoma cells treated with ALA and/or FAC was measured. Cell phantoms containing glioblastoma cells and Wistar rats bearing C
6
glioblastoma were imaged using a 3 T MRI scanner after sequential administration of ALA and FAC. The relaxivity and QSM analysis were performed on the images.
Results
The intra-cellular iron deposition was significantly higher in the glioma cells with sequential treatment of ALA and FAC for 6 h compared to those treated with the controls. The relaxivity and magnetic susceptibility values of the glioblastoma cells and rat brain tumors treated with ALA + FAC (115 ± 5 s-1 for
R
2
’, and 0.1 ± 0.02 ppm for magnetic susceptibility) were significantly higher than those treated with the controls (55 ± 18 (FAC), 45 ± 15 (ALA) s-1 for
R
2
’,
p
< 0.05, and 0.03 ± 0.03 (FAC), 0.02 ± 0.02 (ALA) ppm for magnetic susceptibility,
p
< 0.05).
Discussion
Sequential administration of ALA and iron supplements increases the iron deposition in glioblastoma cells, enabling clinical 3 T MRI to detect GBM using R
2
’ or QSM.</description><identifier>ISSN: 0968-5243</identifier><identifier>EISSN: 1352-8661</identifier><identifier>DOI: 10.1007/s10334-021-00978-1</identifier><identifier>PMID: 34878619</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Aminolevulinic Acid ; Animals ; Basic Science - Molecular and cellular imaging ; Biomedical Engineering and Bioengineering ; Computer Appl. in Life Sciences ; Glioblastoma - diagnostic imaging ; Health Informatics ; Imaging ; Iron ; Magnetic Resonance Imaging - methods ; Medicine ; Medicine & Public Health ; Radiology ; Rats ; Rats, Wistar ; Research Article ; Solid State Physics</subject><ispartof>Magma (New York, N.Y.), 2022-02, Vol.35 (1), p.3-15</ispartof><rights>The Author(s), under exclusive licence to European Society for Magnetic Resonance in Medicine and Biology (ESMRMB) 2021</rights><rights>2021. The Author(s), under exclusive licence to European Society for Magnetic Resonance in Medicine and Biology (ESMRMB).</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-ed60e405d08a159f212da846a175d1ccddf0c47ea1922411b68ba740c44a2fc93</citedby><cites>FETCH-LOGICAL-c347t-ed60e405d08a159f212da846a175d1ccddf0c47ea1922411b68ba740c44a2fc93</cites><orcidid>0000-0001-9260-4001</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34878619$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ebrahimpour, Anita</creatorcontrib><creatorcontrib>Tirgar, Fatemeh</creatorcontrib><creatorcontrib>Hajipour-Verdom, Behnam</creatorcontrib><creatorcontrib>Abbasi, Ardeshir</creatorcontrib><creatorcontrib>Hadjighassem, Mahmoudreza</creatorcontrib><creatorcontrib>Abdolmaleki, Parviz</creatorcontrib><creatorcontrib>Hosseindoost, Saereh</creatorcontrib><creatorcontrib>Javadi, Seyed Amir Hossein</creatorcontrib><creatorcontrib>Hashemi, Hassan</creatorcontrib><creatorcontrib>Foroushani, Abbas Rahimi</creatorcontrib><creatorcontrib>Alam, Nader Riyahi</creatorcontrib><creatorcontrib>Khoobi, Mehdi</creatorcontrib><title>Detection of glioblastoma multiforme using quantitative molecular magnetic resonance imaging based on 5-aminolevulinic acid: in vitro and in vivo studies</title><title>Magma (New York, N.Y.)</title><addtitle>Magn Reson Mater Phy</addtitle><addtitle>MAGMA</addtitle><description>Objectives
We demonstrated a novel metabolic method based on sequential administration of 5-aminolevulinic acid (ALA) and iron supplement, and ferric ammonium citrate (FAC), for glioblastoma multiforme (GBM) detection using R
2
’ and quantitative susceptibility mapping (QSM).
Materials and methods
Intra-cellular iron accumulation in glioblastoma cells treated with ALA and/or FAC was measured. Cell phantoms containing glioblastoma cells and Wistar rats bearing C
6
glioblastoma were imaged using a 3 T MRI scanner after sequential administration of ALA and FAC. The relaxivity and QSM analysis were performed on the images.
Results
The intra-cellular iron deposition was significantly higher in the glioma cells with sequential treatment of ALA and FAC for 6 h compared to those treated with the controls. The relaxivity and magnetic susceptibility values of the glioblastoma cells and rat brain tumors treated with ALA + FAC (115 ± 5 s-1 for
R
2
’, and 0.1 ± 0.02 ppm for magnetic susceptibility) were significantly higher than those treated with the controls (55 ± 18 (FAC), 45 ± 15 (ALA) s-1 for
R
2
’,
p
< 0.05, and 0.03 ± 0.03 (FAC), 0.02 ± 0.02 (ALA) ppm for magnetic susceptibility,
p
< 0.05).
Discussion
Sequential administration of ALA and iron supplements increases the iron deposition in glioblastoma cells, enabling clinical 3 T MRI to detect GBM using R
2
’ or QSM.</description><subject>Aminolevulinic Acid</subject><subject>Animals</subject><subject>Basic Science - Molecular and cellular imaging</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Computer Appl. in Life Sciences</subject><subject>Glioblastoma - diagnostic imaging</subject><subject>Health Informatics</subject><subject>Imaging</subject><subject>Iron</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Radiology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Research Article</subject><subject>Solid State Physics</subject><issn>0968-5243</issn><issn>1352-8661</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kc1u1TAQhS1ERS8tL8ACeckmYDtO4rBD5VeqxIaurYk9uXLl2K1_rsSj9G1xSWHJajQz3znSzCHkNWfvOGPT-8xZ38uOCd4xNk-q48_IgfeD6NQ48ufkwOZRdYOQ_Tl5mfMta-TA-hfkvJdqUiOfD-ThExY0xcVA40qP3sXFQy5xA7pVX9wa04a0ZheO9L5CKK5AcSekW_RoqodENzgGLM7QhDkGCAapa7NHxQIZLW3eQwebC01yqt6FxoJx9gN1gZ5cSZFCsHtzijSXah3mS3K2gs_46qlekJsvn39efeuuf3z9fvXxujO9nEqHdmQo2WCZAj7Mq-DCgpIj8Gmw3BhrV2bkhMBnISTny6gWmGSbSRCrmfsL8nb3vUvxvmIuenPZoPcQMNasxcgUF9MsZUPFjpoUc0646rvUTk2_NGf6MRK9R6Lbo_WfSDRvojdP_nXZ0P6T_M2gAf0O5LYKR0z6NtYU2s3_s_0NnXWapA</recordid><startdate>20220201</startdate><enddate>20220201</enddate><creator>Ebrahimpour, Anita</creator><creator>Tirgar, Fatemeh</creator><creator>Hajipour-Verdom, Behnam</creator><creator>Abbasi, Ardeshir</creator><creator>Hadjighassem, Mahmoudreza</creator><creator>Abdolmaleki, Parviz</creator><creator>Hosseindoost, Saereh</creator><creator>Javadi, Seyed Amir Hossein</creator><creator>Hashemi, Hassan</creator><creator>Foroushani, Abbas Rahimi</creator><creator>Alam, Nader Riyahi</creator><creator>Khoobi, Mehdi</creator><general>Springer International Publishing</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9260-4001</orcidid></search><sort><creationdate>20220201</creationdate><title>Detection of glioblastoma multiforme using quantitative molecular magnetic resonance imaging based on 5-aminolevulinic acid: in vitro and in vivo studies</title><author>Ebrahimpour, Anita ; Tirgar, Fatemeh ; Hajipour-Verdom, Behnam ; Abbasi, Ardeshir ; Hadjighassem, Mahmoudreza ; Abdolmaleki, Parviz ; Hosseindoost, Saereh ; Javadi, Seyed Amir Hossein ; Hashemi, Hassan ; Foroushani, Abbas Rahimi ; Alam, Nader Riyahi ; Khoobi, Mehdi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-ed60e405d08a159f212da846a175d1ccddf0c47ea1922411b68ba740c44a2fc93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Aminolevulinic Acid</topic><topic>Animals</topic><topic>Basic Science - Molecular and cellular imaging</topic><topic>Biomedical Engineering and Bioengineering</topic><topic>Computer Appl. in Life Sciences</topic><topic>Glioblastoma - diagnostic imaging</topic><topic>Health Informatics</topic><topic>Imaging</topic><topic>Iron</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Radiology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Research Article</topic><topic>Solid State Physics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ebrahimpour, Anita</creatorcontrib><creatorcontrib>Tirgar, Fatemeh</creatorcontrib><creatorcontrib>Hajipour-Verdom, Behnam</creatorcontrib><creatorcontrib>Abbasi, Ardeshir</creatorcontrib><creatorcontrib>Hadjighassem, Mahmoudreza</creatorcontrib><creatorcontrib>Abdolmaleki, Parviz</creatorcontrib><creatorcontrib>Hosseindoost, Saereh</creatorcontrib><creatorcontrib>Javadi, Seyed Amir Hossein</creatorcontrib><creatorcontrib>Hashemi, Hassan</creatorcontrib><creatorcontrib>Foroushani, Abbas Rahimi</creatorcontrib><creatorcontrib>Alam, Nader Riyahi</creatorcontrib><creatorcontrib>Khoobi, Mehdi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Magma (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ebrahimpour, Anita</au><au>Tirgar, Fatemeh</au><au>Hajipour-Verdom, Behnam</au><au>Abbasi, Ardeshir</au><au>Hadjighassem, Mahmoudreza</au><au>Abdolmaleki, Parviz</au><au>Hosseindoost, Saereh</au><au>Javadi, Seyed Amir Hossein</au><au>Hashemi, Hassan</au><au>Foroushani, Abbas Rahimi</au><au>Alam, Nader Riyahi</au><au>Khoobi, Mehdi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Detection of glioblastoma multiforme using quantitative molecular magnetic resonance imaging based on 5-aminolevulinic acid: in vitro and in vivo studies</atitle><jtitle>Magma (New York, N.Y.)</jtitle><stitle>Magn Reson Mater Phy</stitle><addtitle>MAGMA</addtitle><date>2022-02-01</date><risdate>2022</risdate><volume>35</volume><issue>1</issue><spage>3</spage><epage>15</epage><pages>3-15</pages><issn>0968-5243</issn><eissn>1352-8661</eissn><abstract>Objectives
We demonstrated a novel metabolic method based on sequential administration of 5-aminolevulinic acid (ALA) and iron supplement, and ferric ammonium citrate (FAC), for glioblastoma multiforme (GBM) detection using R
2
’ and quantitative susceptibility mapping (QSM).
Materials and methods
Intra-cellular iron accumulation in glioblastoma cells treated with ALA and/or FAC was measured. Cell phantoms containing glioblastoma cells and Wistar rats bearing C
6
glioblastoma were imaged using a 3 T MRI scanner after sequential administration of ALA and FAC. The relaxivity and QSM analysis were performed on the images.
Results
The intra-cellular iron deposition was significantly higher in the glioma cells with sequential treatment of ALA and FAC for 6 h compared to those treated with the controls. The relaxivity and magnetic susceptibility values of the glioblastoma cells and rat brain tumors treated with ALA + FAC (115 ± 5 s-1 for
R
2
’, and 0.1 ± 0.02 ppm for magnetic susceptibility) were significantly higher than those treated with the controls (55 ± 18 (FAC), 45 ± 15 (ALA) s-1 for
R
2
’,
p
< 0.05, and 0.03 ± 0.03 (FAC), 0.02 ± 0.02 (ALA) ppm for magnetic susceptibility,
p
< 0.05).
Discussion
Sequential administration of ALA and iron supplements increases the iron deposition in glioblastoma cells, enabling clinical 3 T MRI to detect GBM using R
2
’ or QSM.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>34878619</pmid><doi>10.1007/s10334-021-00978-1</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0001-9260-4001</orcidid></addata></record> |
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| identifier | ISSN: 0968-5243 |
| ispartof | Magma (New York, N.Y.), 2022-02, Vol.35 (1), p.3-15 |
| issn | 0968-5243 1352-8661 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2608127944 |
| source | Springer Nature |
| subjects | Aminolevulinic Acid Animals Basic Science - Molecular and cellular imaging Biomedical Engineering and Bioengineering Computer Appl. in Life Sciences Glioblastoma - diagnostic imaging Health Informatics Imaging Iron Magnetic Resonance Imaging - methods Medicine Medicine & Public Health Radiology Rats Rats, Wistar Research Article Solid State Physics |
| title | Detection of glioblastoma multiforme using quantitative molecular magnetic resonance imaging based on 5-aminolevulinic acid: in vitro and in vivo studies |
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