Stochastic mathematical models for the spread of COVID-19: a novel epidemiological approach

• Published in: Mathematical medicine and biology 2022-02, Vol.39 (1), p.49-76
• Main Authors: Mourad, Ayman, Mroue, Fatima, Taha, Zahraa
• Format: Article
• Language: English
• Subjects: Contact Tracing - methods; COVID-19; Humans; Models, Theoretical; Quarantine; SARS-CoV-2
• ISSN: 1477-8599; 1477-8602
• DOI: 10.1093/imammb/dqab019

Abstract In this paper, three stochastic mathematical models are developed for the spread of the coronavirus disease (COVID-19). These models take into account the known special characteristics of this disease such as the existence of infectious undetected cases and the different social and infectiousness conditions of infected people. In particular, they include a novel approach that considers the social structure, the fraction of detected cases over the real total infected cases, the influx of undetected infected people from outside the borders, as well as contact-tracing and quarantine period for travellers. Two of these models are discrete time–discrete state space models (one is simplified and the other is complete) while the third one is a continuous time–continuous state space stochastic integro-differential model obtained by a formal passing to the limit from the proposed simplified discrete model. From a numerical point of view, the particular case of Lebanon has been studied and its reported data have been used to estimate the complete discrete model parameters, which can be of interest in estimating the spread of COVID-19 in other countries. The obtained simulation results have shown a good agreement with the reported data. Moreover, a parameters’ analysis is presented in order to better understand the role of some of the parameters. This may help policy makers in deciding on different social distancing measures.