Lipoprotein(a) as predictor of coronary artery disease and myocardial infarction in a multi-ethnic Asian population

The role of Lp(a) in multi-ethnic Asian populations with coronary artery disease (CAD) has not been well established. The aims of this study were (i) to investigate whether Lp(a) is a predictor of CAD, and (ii) amongst patients with CAD, to ascertain whether Lp(a) is a predictor of acute myocardial...

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Published in:Atherosclerosis 2022-05, Vol.349, p.160-165
Main Authors: Loh, Wann Jia, Chang, Xuling, Aw, Tar Choon, Phua, Soon Kieng, Low, Adrian F., Chan, Mark Yan-Yee, Watts, Gerald F., Heng, Chew-Kiat
Format: Article
Language:English
Subjects:
Coronary Angiography
Coronary artery disease
Coronary Artery Disease - diagnostic imaging
Coronary Artery Disease - epidemiology
Coronary Stenosis - diagnostic imaging
Coronary Stenosis - epidemiology
Ethnicity
Female
Humans
Lipoprotein (a)
Male
Myocardial infarction
Myocardial Infarction - diagnosis
Myocardial Infarction - epidemiology
Risk Factors
Severity of Illness Index
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Summary:The role of Lp(a) in multi-ethnic Asian populations with coronary artery disease (CAD) has not been well established. The aims of this study were (i) to investigate whether Lp(a) is a predictor of CAD, and (ii) amongst patients with CAD, to ascertain whether Lp(a) is a predictor of acute myocardial infarction (AMI) and severity of CAD. We compared three cardiovascular phenotypes from patients recruited at coronary angiography. CAD was defined as ≥50% coronary artery stenosis and subdivided into a group with AMI history (CAD+AMI+) and a group without (CAD+AMI-). Minimal CAD group (CAD-) was defined as normal or
ISSN:0021-9150
1879-1484
DOI:10.1016/j.atherosclerosis.2021.11.018