Sleep and daytime behavior in individuals with Christianson Syndrome

The objectives of this study were to: 1) characterize the sleep behaviors and symptoms of individuals with Christianson Syndrome (CS) by means of validated questionnaires; and 2) determine their associations with daytime emotional and behavioral symptoms in this population. Participants included 16...

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Bibliographic Details
Published in:Sleep medicine 2022-01, Vol.89, p.55-59
Main Authors: Gruber, Reut, Scholes, Samantha, Bertone, Armando, McKinney, R Anne, Orlowski, John, Wise, Merrill S.
Format: Article
Language:English
Subjects:
Ataxia
Child
Christianson syndrome
Daytime functioning
Epilepsy - complications
Genetic Diseases, X-Linked - complications
Humans
Intellectual Disability
Male
Microcephaly
Neurodevelopmental disorders
Ocular Motility Disorders - complications
Sleep
Sleep Wake Disorders - complications
Surveys and Questionnaires
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Summary:The objectives of this study were to: 1) characterize the sleep behaviors and symptoms of individuals with Christianson Syndrome (CS) by means of validated questionnaires; and 2) determine their associations with daytime emotional and behavioral symptoms in this population. Participants included 16 boys genetically diagnosed with CS, between 2.5 and 40 years of age (M = 14.5 ± 8.08). Parents completed questionnaires regarding the sleep, daytime behavior, and health of their child. Of the participants, 31% did not obtain the recommended amount of sleep for their age, 43% experienced a prolonged sleep latency, and 88% had a clinical or sub-clinical score for at least one subscale of the Sleep Disturbance Scale for Children (SDSC). Specific problems detected included insomnia, sleep–wake transition disorders, periodic limb movements in sleep, and sleep related breathing disorders. About half of the participants manifested emotional and behavioral problems at clinical levels. Higher levels of sleep disturbances were associated with higher levels of behavioral and emotional daytime symptoms. Sleep problems are common in individuals with CS and are associated with daytime behavioral and emotional symptoms. •Sleep problems are common in individuals with Christianson syndrome (CS).•Individuals with CS presented with clinical levels of Insomnia, PLMD and SRBD.•Sleep disturbances are associated with daytime symptoms in individuals with CS.
ISSN:1389-9457
1878-5506
DOI:10.1016/j.sleep.2021.11.007