Sinomenine attenuates alcohol-induced acute liver injury via inhibiting oxidative stress, inflammation and apoptosis in mice

•SIN protects from alcohol-induced ALI.•SIN reduced oxidative stress by enhancing antioxidant enzyme levels and Nrf2/HO-1.•SIN decreased inflammation by inhibiting NLRP3 inflammasome and Akt/NF-κB pathway.•SIN inhibited apoptotic protein levels and down-regulated MAPK expressions.

Saved in:
Bibliographic Details
Published in:Food and chemical toxicology 2022-01, Vol.159, p.112759-112759, Article 112759
Main Authors: Fan, Hui, Tu, Tingting, Zhang, Xiao, Yang, Qiankun, Liu, Gang, Zhang, Tianmeng, Bao, Yu, Lu, Yuhe, Dong, Zibo, Dong, Jingquan, Zhao, Panpan
Format: Article
Language:English
Subjects:
Animals
Apoptosis - drug effects
Chemical and Drug Induced Liver Injury - metabolism
Inflammation - metabolism
Liver - drug effects
Male
Mice
Mice, Inbred BALB C
Morphinans - pharmacology
Oxidative Stress - drug effects
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•SIN protects from alcohol-induced ALI.•SIN reduced oxidative stress by enhancing antioxidant enzyme levels and Nrf2/HO-1.•SIN decreased inflammation by inhibiting NLRP3 inflammasome and Akt/NF-κB pathway.•SIN inhibited apoptotic protein levels and down-regulated MAPK expressions.
ISSN:0278-6915
1873-6351
DOI:10.1016/j.fct.2021.112759