Differences in bovine placentome blood vessel density and transcriptomics in a mid to late-gestating maternal nutrient restriction model

Prenatal development is reliant on a functioning placenta, which can be influenced by maternal nutrition. Moreover, the variation in cotyledonary capacity within an animal has not been fully examined to date. Therefore, the purpose of this study was to determine the effect of (1) placentome size and...

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Bibliographic Details
Published in:Placenta (Eastbourne) 2022-01, Vol.117, p.122-130
Main Authors: Reid, Dana S., Burnett, Derris D., Contreras-Correa, Zully E., Lemley, Caleb O.
Format: Article
Language:English
Subjects:
Animals
Bovine
Cattle
Cotyledon
Female
Food Deprivation - physiology
Gene Expression
Maternal Nutritional Physiological Phenomena
Nutrient restriction
Placenta - blood supply
Placenta - metabolism
Placentome
Pregnancy
Transcriptome
Vascularity
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Summary:Prenatal development is reliant on a functioning placenta, which can be influenced by maternal nutrition. Moreover, the variation in cotyledonary capacity within an animal has not been fully examined to date. Therefore, the purpose of this study was to determine the effect of (1) placentome size and (2) maternal nutrient restriction on molecular, microscopic, and macroscopic features of bovine placentomes during late gestation. Pregnant cows (n = 6) were placed into one of 2 treatments: CON (100% NRC) vs RES (60% of NRC) from day 140 until slaughter at day 240 of gestation. Placentomes of various sizes were perfused to assess macroscopic blood vessel density of the cotyledon. Microscopic imaging and RNA extraction for sequencing was performed. Macroscopic blood vessel density relative to placentome weight was not different (P = 0.42) among small, medium, or large placentomes. Cotyledonary microscopic blood vessel number, area, and perimeter was increased (P 
ISSN:0143-4004
1532-3102
DOI:10.1016/j.placenta.2021.12.004