Gastric acid-response chitosan/alginate/tilapia collagen peptide composite hydrogel: Protection effects on alcohol-induced gastric mucosal injury

Long-term excessive alcohol intake can easily lead to gastritis, gastric ulcer, and gastric bleeding. In this paper, the gastric acid-responsive hydrogel of CS-NAC/alginate/tilapia collagen peptide (CS-NAC/ALG/TCP) was developed. Its structure and properties were determined. The alcohol-induced gast...

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Bibliographic Details
Published in:Carbohydrate polymers 2022-02, Vol.277, p.118816-118816, Article 118816
Main Authors: Lu, Sitong, Kong, Songzhi, Wang, Ye, Hu, Zhang, Zhang, Lingyu, Liao, Mingneng
Format: Article
Language:English
Subjects:
Alcohol-induced
Alcohols
Alginates - chemistry
Alginates - pharmacology
Animals
Chitosan - chemistry
Chitosan - pharmacology
Collagen - chemistry
Collagen - pharmacology
Gastric Acid - chemistry
Gastric acid-response
Gastric Mucosa - drug effects
Gastric Mucosa - injuries
Gastric Mucosa - metabolism
Gastric mucosal injure
Hydrogels
Hydrogels - chemistry
Hydrogels - pharmacology
Mice
Mice, Inbred Strains
Peptides - chemistry
Peptides - pharmacology
Protective Agents - chemistry
Protective Agents - pharmacology
Tilapia
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Summary:Long-term excessive alcohol intake can easily lead to gastritis, gastric ulcer, and gastric bleeding. In this paper, the gastric acid-responsive hydrogel of CS-NAC/alginate/tilapia collagen peptide (CS-NAC/ALG/TCP) was developed. Its structure and properties were determined. The alcohol-induced gastric mucosal injury models in mice were established to evaluate the protective effects of CS-NAC/ALG/TCP. The results showed that CS-NAC/ALG/TCP was successfully fabricated, and it showed a sustained release of TCP, strong mucoadhesion, and excellent biodegradability in vitro. In the animal experiments, CS-NAC/ALG/TCP improved the oxidative stress status of the gastric mucosa by increasing the levels of SOD, GSH, and CAT in tissues. It also down-regulated the expression of MPO, TNF-α, IL-1β, and IL-6, and increased the production of gastric protective factors such as PGE2 and NO in mouse stomach, thereby reducing the alcohol-induced inflammation and protecting the gastric mucosal injury. Besides, CS-NAC/ALG/TCP can also increase the activities of alcohol metabolism enzymes to improve alcohol metabolism, thereby reducing alcoholic damage. In conclusion, CS-NAC/ALG/TCP is a promising candidate for the treatment of alcohol-induced gastric injury. [Display omitted]
ISSN:0144-8617
1879-1344
DOI:10.1016/j.carbpol.2021.118816