Dimensional Affective Processing in BD

• Published in: Psychiatry research 2022-01, Vol.307, p.114304-114304, Article 114304
• Main Authors: Migó, Marta, Simpson, Kendra, Peters, Amy, Ellard, Kristen K., Chou, Tina, Nierenberg, Andrew A., Dougherty, Darin D., Deckersbach, Thilo
• Format: Article
• Language: English
• Subjects: Affect - physiology; Affective processing; Bipolar disorder; Bipolar Disorder - diagnosis; Brain - diagnostic imaging; Depression; Emotions - physiology; fMRI; Humans; Magnetic Resonance Imaging - methods; Mania
• ISSN: 0165-1781; 1872-7123
• DOI: 10.1016/j.psychres.2021.114304

•MSIT-IAPS was used to explore affective processing in BD.•Neural activation during affective processing correlated with BD symptom severity.•Mania and depression correlated with prefrontal, parietal, and limbic activation.•Future research should dimensionally study BD symptom severities. Bipolar Disorder (BD) involves altered neural affective processing, but studies comparing BD patients to controls have yielded inconsistent results. This might relate to substantial variability in the nature and severity of mood symptoms among individuals with BD. Hence, we dimensionally examined the relationship between depressive and manic symptom severity and neural responses to positive and negative affective stimuli. 39 Participants with BD completed measures of depression and mania severity prior to completing a cognitive-affective processing task during fMRI. A multiple regression model was run in SPM to identify brain regions correlated with depressive and manic symptoms during positive-neutral and negative-neutral contrasts. A-priori anatomical ROIs were defined bilaterally in frontal, parietal and limbic regions. Results showed that depression severity was associated with increased activation in frontal, parietal, and limbic ROIs, regardless of valence. Mania severity was correlated with both increased and decreased activation, particularly within frontal subdivisions and during the processing of positively valenced images. In conclusion, dimensional modeling of symptom severity captures variance in neural responses to affect, which may have been previously undetected due to heterogeneity when examined at the group level. Future fMRI studies comparing BD patients and controls should account for symptom variability in BD.