The potential pharmacological mechanisms of β-hydroxybutyrate for improving cognitive functions

β-Hydroxybutyl acid (βOHB), the most prevalent type of ketone in the human body, is involved in the pathogenesis of cognitive disorders, especially Alzheimer’s dementia (AD), through a variety of mechanisms, such as enhancing mitochondrial metabolism, regulating signaling molecule, increasing histon...

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Bibliographic Details
Published in:Current opinion in pharmacology 2022-02, Vol.62, p.15-22
Main Authors: Wang, Jian-Hong, Guo, Lei, Wang, Su, Yu, Neng-Wei, Guo, Fu-Qiang
Format: Article
Language:English
Subjects:
3-Hydroxybutyric Acid - metabolism
3-Hydroxybutyric Acid - pharmacology
Acetylation
Alzheimer Disease - drug therapy
Alzheimer Disease - metabolism
Amyloid beta-Peptides - metabolism
Cognition
Humans
Mitochondria - metabolism
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Summary:β-Hydroxybutyl acid (βOHB), the most prevalent type of ketone in the human body, is involved in the pathogenesis of cognitive disorders, especially Alzheimer’s dementia (AD), through a variety of mechanisms, such as enhancing mitochondrial metabolism, regulating signaling molecule, increasing histone acetylation, affecting the metabolism of Aβ and Tau proteins, inhibiting inflammation and lipid metabolism, and regulating intestinal microbes. Based on the above findings, clinical drug development in AD has begun to focus on βOHB.
ISSN:1471-4892
1471-4973
DOI:10.1016/j.coph.2021.10.005