Gene therapy: A promising approach for breast cancer treatment

Breast cancer (BC) is the most prevalent malignancy and the second leading cause of death among women worldwide that is caused by numerous genetic and environmental factors. Hence, effective treatment for this type of cancer requires new therapeutic approaches. The traditional methods for treating t...

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Bibliographic Details
Published in:Cell biochemistry and function 2022-01, Vol.40 (1), p.28-48
Main Authors: Dastjerd, Niloufar Tavakoli, Valibeik, Ali, Rahimi Monfared, Sobhan, Goodarzi, Golnaz, Moradi Sarabi, Mostafa, Hajabdollahi, Faezeh, Maniati, Mahmood, Amri, Jamal, Samavarchi Tehrani, Sadra
Format: Article
Language:English
Subjects:
Breast cancer
breast neoplasms
Breast Neoplasms - genetics
Breast Neoplasms - therapy
Cancer therapies
CAR T‐ cell therapy
CRISPER/Cas9
delivery methods
Environmental factors
Female
gene editing
Gene therapy
Genetic Therapy
Humans
Malignancy
nanoparticles
Side effects
Tumors
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Summary:Breast cancer (BC) is the most prevalent malignancy and the second leading cause of death among women worldwide that is caused by numerous genetic and environmental factors. Hence, effective treatment for this type of cancer requires new therapeutic approaches. The traditional methods for treating this cancer have side effects, therefore so much research have been performed in last decade to find new methods to alleviate these problems. The study of the molecular basis of breast cancer has led to the introduction of gene therapy as an effective therapeutic approach for this cancer. Gene therapy involves sending genetic material through a vector into target cells, which is followed by a correction, addition, or suppression of the gene. In this technique, it is necessary to target tumour cells without affecting normal cells. In addition, clinical trial studies have shown that this approach is less toxic than traditional therapies. This study will review various aspects of breast cancer, gene therapy strategies, limitations, challenges and recent studies in this area.
ISSN:0263-6484
1099-0844
DOI:10.1002/cbf.3676