2-Aminopyridine - an unsung hero in drug discovery

2-Aminopyridine is a simple, low molecular weight and perfectly functionalised moiety known for the synthesis of diverse biological molecules. Many pharmaceutical companies across the globe aim to synthesise low-molecular weight molecules for use as pharmacophores against various biological targets....

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2022-01, Vol.58 (3), p.343-382
Main Authors: Rao, Ramdas Nishanth, Chanda, Kaushik
Format: Article
Language:English
Subjects:
Aminopyridines - chemical synthesis
Aminopyridines - chemistry
Chemical synthesis
Drug Discovery
Low molecular weights
Metabolites
Molecular Structure
Molecular weight
Pharmacology
Toxicity
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Summary:2-Aminopyridine is a simple, low molecular weight and perfectly functionalised moiety known for the synthesis of diverse biological molecules. Many pharmaceutical companies across the globe aim to synthesise low-molecular weight molecules for use as pharmacophores against various biological targets. 2-Aminopyridine can serve as a perfect locomotive in the synthesis and pulling of such molecules towards respective pharmacological goals. The major advantage of this moiety is its simple design, which can be used to produce single products with minimum side reactions. Moreover, the exact weight of synthesised compounds is low, which enables facile identification of toxicity-causing metabolites in drug discovery programmes. This manuscript is a quick review of such pharmacophores derived from 2-aminopyridine. 2-Aminopyridine is a simple, low molecular weight and perfectly functionalised moiety known for the synthesis of diverse biological molecules.
ISSN:1359-7345
1364-548X
DOI:10.1039/d1cc04602k