Four genomic clades of Candida auris identified in Canada, 2012–2019

Abstract Candida auris is an emerging yeast that is associated with antifungal resistance and healthcare-associated outbreaks. From 2012 to 2019, there were 24 known cases of C. auris colonization or infection in Canada. Isolates were from axilla/groin (n = 6), ear (n = 5), blood (n = 4), toe (n = 2...

Full description

Saved in:
Bibliographic Details
Published in:Medical mycology (Oxford) 2022-01, Vol.60 (1)
Main Authors: De Luca, Domenica G, Alexander, David C, Dingle, Tanis C, Dufresne, Philippe J, Hoang, Linda M, Kus, Julianne V, Schwartz, Ilan S, Mulvey, Michael R, Bharat, Amrita
Format: Article
Language:English
Subjects:
Animals
Antifungal Agents - pharmacology
Antifungal Agents - therapeutic use
Canada - epidemiology
Candida - genetics
Candida auris
Genomics
Microbial Sensitivity Tests - veterinary
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Candida auris is an emerging yeast that is associated with antifungal resistance and healthcare-associated outbreaks. From 2012 to 2019, there were 24 known cases of C. auris colonization or infection in Canada. Isolates were from axilla/groin (n = 6), ear (n = 5), blood (n = 4), toe (n = 2), and a variety of other sites (n = 7). Canadian isolates belonged to the four main genomic clades: Clade I (formerly called South Asian clade, n = 12), Clade II (East Asian, n = 3), Clade III (African, n = 4), and Clade IV (South American, n = 5). Isolates within each clade were clonal; however, whole genome sequencing may be helpful in identifying clusters within healthcare facilities. Lay summary The fungal pathogen Candida auris has caused many hospital outbreaks and is often multidrug resistant. All four major strains of C. auris were identified in Canada from 2012 to 2019. Genomic epidemiology may be useful for identifying and reducing transmission of C. auris within hospitals.
ISSN:1369-3786
1460-2709
DOI:10.1093/mmy/myab079