Assessing inter-rater reproducibility in MScanFit MUNE in a 6-subject, 12-rater “Round Robin” setup

To assess the inter-rater reliability of MScanFit MUNE using a “Round Robin” research design. Twelve raters from different centres examined six healthy study participants over two days. Median, ulnar and common peroneal nerves were stimulated, and compound muscle action potential (CMAP)-scans were r...

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Published in:Neurophysiologie clinique 2022-04, Vol.52 (2), p.157-169
Main Authors: Sørensen, Daniel Mosgaard, Bostock, Hugh, Ballegaard, Martin, Fuglsang-Frederiksen, Anders, Graffe, Carolina Canillo, Grötting, Arnstein, Jones, Kelvin, Kallio, Mika, Krarup, Christian, Krøigård, Thomas, Lupescu, Tudor, Maitland, Stuart, Moldovan, Mihai, Nilsen, Kristian Bernhard, Pugdahl, Kirsten, Santos, Miguel Oliveira, Themistocleous, Andreas Constantinos, Zlateva, Suzana Slavica, Ööpik, Merle, Tankisi, Hatice
Format: Article
Language:English
Subjects:
Action potential
Action Potentials - physiology
Amyotrophic Lateral Sclerosis
Clinical trials
Electromyography - methods
Humans
Inter-rater variability
Motor neurone disease
Motor Neurons - physiology
Motor unit number estimation
MScanFit MUNE
Muscle, Skeletal - innervation
Muscles
Nerves
Neurodegenerative Disease
Pain
Pain perception
Reproducibility
Reproducibility of Results
Statistical analysis
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Summary:To assess the inter-rater reliability of MScanFit MUNE using a “Round Robin” research design. Twelve raters from different centres examined six healthy study participants over two days. Median, ulnar and common peroneal nerves were stimulated, and compound muscle action potential (CMAP)-scans were recorded from abductor pollicis brevis (APB), abductor digiti minimi (ADM) and anterior tibial (TA) muscles respectively. From this we calculated the Motor Unit Number Estimation (MUNE) and “A50”, a motor unit size parameter. As statistical analysis we used the measures Limits of Agreement (LOA) and Coefficient of Variation (COV). Study participants scored their perception of pain from the examinations on a rating scale from 0 (no pain) to 10 (unbearable pain). Before this study, 41.6% of the raters had performed MScanFit less than five times. The mean MUNE-values were: 99.6 (APB), 131.4 (ADM) and 126.2 (TA), with LOA: 19.5 (APB), 29.8 (ADM) and 20.7 (TA), and COV: 13.4 (APB), 6.3 (ADM) and 5.6 (TA). MUNE-values correlated to CMAP max amplitudes (R2-values were: 0.463 (APB) (p
ISSN:0987-7053
1769-7131
DOI:10.1016/j.neucli.2021.11.002