Multifunctional applications of natural polysaccharide starch and cellulose: An update on recent advances

The emergence of clinical complications and therapeutic challenges for treating various diseases necessitate the discovery of novel restorative functional materials. Polymer-based drug delivery systems have been extensively reported in the last two decades. Recently, there has been an increasing int...

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Bibliographic Details
Published in:Biomedicine & pharmacotherapy 2022-02, Vol.146, p.112492-112492, Article 112492
Main Authors: Gopinath, V., Kamath, S. Manjunath, Priyadarshini, S., Chik, Zamri, Alarfaj, Abdullah A., Hirad, Abdurahman H.
Format: Article
Language:English
Subjects:
Animals
Anti-Infective Agents
Anticancer
Antimicrobials
Cellulose
Cross-linking
Drug delivery
Drug Delivery Systems
Food Packaging
Gene Transfer Techniques
Humans
Starch
Tissue Engineering
Wound healing
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Summary:The emergence of clinical complications and therapeutic challenges for treating various diseases necessitate the discovery of novel restorative functional materials. Polymer-based drug delivery systems have been extensively reported in the last two decades. Recently, there has been an increasing interest in the progression of natural biopolymers based controlled therapeutic strategies, especially in drug delivery and tissue engineering applications. However, the solubility and functionalisation due to their complex network structure and intramolecular bonding seem challenging. This review explores the current advancement and prospects of the most promising natural polymers such as cellulose, starch and their derivatives-based drug delivery vehicles like hydrogels, films and composites, in combating major ailments such as bone infections, microbial infections, and cancers. In addition, selective drug targeting using metal–drug (MD) and MD-based polymeric missiles have been exciting but challenging for its application in cancer therapeutics. Owing to high biocompatibility of starch and cellulose, these materials have been extensively evaluated in biomedical and pharmaceutical applications. This review presents a detailed impression of the current trends for the construction of biopolymer-based tissue engineering, drug/gene/protein delivery vehicles. [Display omitted]
ISSN:0753-3322
1950-6007
DOI:10.1016/j.biopha.2021.112492