Formation of lipid tubules induced by a sugar-like molecule myo -inositol

The sugar-like molecule -inositol (InOH) bears an uncanny structural resemblance to the pyranose form of the sugar D-glucose (DG). InOH and its derivatives play a pivotal role in cell biology; whereby its interaction with the model membrane needs to be studied. Here, we have demonstrated that lipid...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2022-01, Vol.58 (3), p.459-462
Main Authors: Ghosh, Meghna, Nandi, Sourav, Layek, Souvik, Nandi, Pratyush Kiran, Bera, Nanigopal, Sarkar, Nilmoni
Format: Article
Language:English
Subjects:
Inositols
Lipids
Membranes
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Summary:The sugar-like molecule -inositol (InOH) bears an uncanny structural resemblance to the pyranose form of the sugar D-glucose (DG). InOH and its derivatives play a pivotal role in cell biology; whereby its interaction with the model membrane needs to be studied. Here, we have demonstrated that lipid tubules are formed as a result of the above-said interactions and that these interactions can be prevented by using hydroxyl protected InOH derivatives. We have tried to elucidate the nature of the InOH-membrane interactions by comparing them with DG-membrane interactions and have proposed a mechanism for the same.
ISSN:1359-7345
1364-548X
DOI:10.1039/d1cc05620d