A half century of fish gonadotropin‐releasing hormones: Breaking paradigms

The field of fish gonadotropin‐releasing hormones (GnRHs) is also celebrating its 50th anniversary this year. This review provides a chronological history of fish GnRH biology over the past five decades. It demonstrates how discoveries in fish regarding GnRH and GnRH receptor multiplicity, dynamic i...

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Bibliographic Details
Published in:Journal of neuroendocrinology 2022-05, Vol.34 (5), p.e13069-n/a
Main Authors: Zohar, Yonathan, Zmora, Nilli, Trudeau, Vance L., Muñoz‐Cueto, José A., Golan, Matan
Format: Article
Language:English
Subjects:
gene duplication
GnRH multiplicity
Gonadotropin-releasing hormone
Gonadotropins
hypothalamic–pituitary–gonadal axis
Mammals
Pituitary (anterior)
reproduction
teleosts
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Summary:The field of fish gonadotropin‐releasing hormones (GnRHs) is also celebrating its 50th anniversary this year. This review provides a chronological history of fish GnRH biology over the past five decades. It demonstrates how discoveries in fish regarding GnRH and GnRH receptor multiplicity, dynamic interactions between GnRH neurons, and additional neuroendocrine factors acting alongside GnRH, amongst others, have driven a paradigm shift in our understanding of GnRH systems and functions in vertebrates, including mammals. The role of technological innovations in enabling scientific discoveries is portrayed, as well as how fundamental research in fish GnRH led to translational outcomes in aquaculture. The interchange between fish and mammalian GnRH research is discussed, as is the value and utility of using fish models for advancing GnRH biology. Current challenges and future perspectives are presented, with the hope of expanding the dialogue and collaborations within the neuroendocrinology scientific community at large, capitalizing on diversifying model animals and the use of comparative strategies. This review provides a concise and chronological history of fish gonadotropin‐releasing hormone (GnRH) biology over the past five decades. It demonstrates how discoveries in fish regarding GnRH and GnRH receptor multiplicity, dynamic interactions between GnRH neurons, and additional neuroendocrine factors acting alongside GnRH, amongst others, have driven a paradigm shift in our understanding of GnRH systems and functions in vertebrates, and especially in mammals.
ISSN:0953-8194
1365-2826
DOI:10.1111/jne.13069