PTEN Loss and PD-L1 Expression of Different Histological Patterns of Prostate Cancer

Although several studies have evaluated PTEN loss in Prostatic Adenocarcinoma (PCa), PTEN loss correlation with different histological patterns only has a few studies. Although several studies have evaluated PD-L1 expression in PCa and its correlation with Gleason scores, as far as we know, there ar...

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Bibliographic Details
Published in:Pathology, research and practice research and practice, 2022-01, Vol.229, p.153738-153738, Article 153738
Main Authors: Kir, Gozde, Cecikoglu, Gozde Ecem, Olgun, Zeynep Cagla, Kazan, Huseyin Ozgur, Yildirim, Asif
Format: Article
Language:English
Subjects:
Adenocarcinoma - chemistry
Adenocarcinoma - metabolism
Adenocarcinoma - pathology
Architectural pattern
B7-H1 Antigen - analysis
B7-H1 Antigen - biosynthesis
Cribriform pattern
Humans
Male
PD-L1
Prostate cancer
Prostatic Neoplasms - chemistry
Prostatic Neoplasms - metabolism
Prostatic Neoplasms - pathology
PTEN
PTEN Phosphohydrolase - analysis
PTEN Phosphohydrolase - biosynthesis
Retrospective Studies
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Summary:Although several studies have evaluated PTEN loss in Prostatic Adenocarcinoma (PCa), PTEN loss correlation with different histological patterns only has a few studies. Although several studies have evaluated PD-L1 expression in PCa and its correlation with Gleason scores, as far as we know, there are no prior studies that have included a comparison between PD-L1 expression and histological patterns of PCa. This study aims to evaluate PTEN loss and PD-L1 expression by immunohistochemistry in different histological patterns of PCa. The current study included consecutive 98 radical prostatectomy specimens with 151 foci with different Gleason Grade (GG) patterns. The highest frequency of PTEN loss was observed in GG4 cribriform and glomeruloid patterns (59.3%, p 
ISSN:0344-0338
1618-0631
DOI:10.1016/j.prp.2021.153738