Value of serum YKL-40 in the diagnosis of anti-MDA5-positive patients with dermatomyositis complicated with severe pulmonary injury

• Published in: Beijing da xue xue bao. Journal of Peking University. Yi xue ban 2021-12, Vol.53 (6), p.1055-1060
• Main Authors: Zhang, P L, Yang, H X, Zhang, L N, Ge, Y P, Peng, Q L, Wang, G C, Lu, X
• Format: Article
• Language: Chinese
• Subjects: Chitinase-3-Like Protein 1; Dermatomyositis - complications; Female; Humans; Lung Diseases, Interstitial - complications; Lung Diseases, Interstitial - diagnosis; Lung Injury; Male; Retrospective Studies
• ISSN: 1671-167X

To investigate the value of serum and bronchoalveolar lavage fluid (BALF) chitinase-3-like-1 protein (YKL-40) in the diagnosis of anti-melanoma differentiation-associated gene 5 (MDA5)-positive dermatomyositis (DM) patients complicated with serious pulmonary injury, including rapidly progressive interstitial lung disease (RP-ILD) and pulmonary infection. Anti-MDA5 antibodies positive patients with DM who were hospitalized in the Department of Rheumatology of China-Japan Friendship Hospital from 2013 to 2018 were involved in this study. Demographic information, clinical, laboratory and imaging data were retrospectively collected. ELISA was used to detect the serum and BALF levels of YKL-40. The receiver operating characteristic (ROC) curve was drawn, and the area under ROC curve (AUC) was used to evaluate the diagnostic value of serum YKL-40 for pulmonary injury.Interstitial lung disease (ILD) was confirmed by chest high-resolution CT (HRCT). RP-ILD was defined as progressive respiratory symptoms such as dyspn