Clinical characteristics of central nervous system involvement in IgG4 related diseases

• Published in: Beijing da xue xue bao. Journal of Peking University. Yi xue ban 2021-12, Vol.53 (6), p.1043-1048
• Main Authors: Meng, G Y, Zhang, Y X, Liu, Y Y
• Format: Article
• Language: Chinese
• Subjects: Humans; Immunoglobulin G; Immunoglobulin G4-Related Disease; Inflammation; Pituitary Gland; Retrospective Studies
• ISSN: 1671-167X

To improve the understanding of the clinical characteristics of immunoglobulin G4-related disease (IgG4-RD) with central nervous system (CNS) involvement, so as to contribute to the early diagnosis and treatment. In this study, 10 patients with IgG4-RD with CNS involvement were selected. Clinical data including demographic features, clinical manifestations, organ involvement, laboratory findings, radiological results, pathology, treatments and outcomes were collected retrospectively. Among the 10 IgG4-RD patients complicated with CNS involvement, 6 cases manifested as pituitary involvement and 4 cases manifested as dural involvement. Only 2 patients had nervous system involvement alone, while the left patients were complicated with other organ involvement besides nervous system. Half of the patients presented nervous system involvement as the initial manifestation, and the main symptoms of nervous system included polydipsia, polyuria, headache, decreased vision and so on. In the laboratory examination, the se