Apoptotic effects of acacetin in human colon cancer HT-29 and HCT 116 cells

Aim: Acacetin is a natural flavone compound, which is found in several plants as Robinia pseudoacacia and is demonstrated to have anticancerogenic activities in many types of cancer (e.g., human nonsmall cell lung cancer, and prostate). Colorectal carcinoma (CRC) is one of the serious health problem...

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Bibliographic Details
Published in:Journal of cancer research and therapeutics 2021-10, Vol.17 (6), p.1479-1482
Main Authors: Aslan, Beste, Ertugrul, Baris, Iplik, Elif, Cakmakoglu, Bedia
Format: Article
Language:English
Subjects:
Apoptosis
Apoptosis - drug effects
Bioflavonoids
Black locust
Care and treatment
Chemical properties
Colonic Neoplasms - drug therapy
Colonic Neoplasms - pathology
Colorectal cancer
Drug Screening Assays, Antitumor
Flavones
Flavones - pharmacology
Flavones - therapeutic use
Flavonoids
HCT116 Cells
Health aspects
HT29 Cells
Humans
Phytochemicals
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Summary:Aim: Acacetin is a natural flavone compound, which is found in several plants as Robinia pseudoacacia and is demonstrated to have anticancerogenic activities in many types of cancer (e.g., human nonsmall cell lung cancer, and prostate). Colorectal carcinoma (CRC) is one of the serious health problems and is a complex disease. We intended to find a more effective new candidate for the treatment of colon cancer, and hence, we designed this study to investigate the effects of acacetin on CRC (HT-29, HCT 116) in vitro. Methods:The study was carried out with the methods that determine for apoptosis (WST-1, Caspase 3/BCA, Annexin V). Results:Acacetin showed antitumor and apoptosis-inducing effects in the CRC cell lines. Conclusions: Acacetin was effective on CRC cell lines, besides no lethal effect on healthy lung cells (MRC-5).
ISSN:0973-1482
1998-4138
DOI:10.4103/jcrt.JCRT_1097_19