A polysaccharide isolated from Ganoderma lucidum ameliorates hyperglycemia through modulating gut microbiota in type 2 diabetic mice

In this study, we reported a thermal stable and non-toxic heteropolysaccharide F31, which decreased the blood glucose of diabetic mice (21.75 mmol/L) induced by high-fat diet (HFD) and streptozotocin (STZ) to 12.56 and 15.18 mmol/L (P 

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Bibliographic Details
Published in:International journal of biological macromolecules 2022-02, Vol.197, p.23-38
Main Authors: Shao, Weiming, Xiao, Chun, Yong, Tianqiao, Zhang, Yifan, Hu, Huiping, Xie, Ting, Liu, Rongjie, Huang, Longhua, Li, Xiangmin, Xie, Yizhen, Zhang, Jumei, Chen, Shaodan, Cai, Manjun, Chen, Diling, Liu, Yuanchao, Gao, Xiong, Wu, Qingping
Format: Article
Language:English
Subjects:
Animals
Blood Glucose - metabolism
Diabetes Mellitus, Experimental - drug therapy
Diabetes Mellitus, Type 2 - drug therapy
Diabetes Mellitus, Type 2 - metabolism
Diabetes Mellitus, Type 2 - microbiology
Diet, High-Fat - adverse effects
Fungal Polysaccharides - chemistry
Fungal Polysaccharides - pharmacology
Ganoderma lucidum
Gastrointestinal Microbiome - drug effects
Gut microbiota
Heteropolysaccharide
Hyperglycemia - drug therapy
Hypoglycemic
Hypoglycemic Agents - pharmacology
Hypoglycemic Agents - therapeutic use
Insulin - blood
Insulin - metabolism
Insulin Resistance
Male
Mice
Polysaccharides - chemistry
Polysaccharides - pharmacology
Reishi - chemistry
Type 2 diabetes
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Summary:In this study, we reported a thermal stable and non-toxic heteropolysaccharide F31, which decreased the blood glucose of diabetic mice (21.75 mmol/L) induced by high-fat diet (HFD) and streptozotocin (STZ) to 12.56 and 15.18 mmol/L (P 
ISSN:0141-8130
1879-0003
1879-0003
DOI:10.1016/j.ijbiomac.2021.12.034